【体外膜肺ECMO精品课件】 Collaborators’ meeting October 2004.pptVIP

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【体外膜肺ECMO精品课件】 Collaborators’ meeting October 2004.ppt

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Collaborators’ meeting October 2004;The Importance of the CESAR Trial;;;What is the Population ?;Expected Survival;Outcomes for population of patients being studied in CESAR Vasilyev 1995 Morris et al 1994 Peek et al 1997 Pettifer et al 2001 ;Vasilyev; Chest 1995;107:1083-8;Adult ECMO,AIMS DESIGN.;Adult ECMO,INDICATIONS.;PATIENT STATUS AT REFERRAL.;SURVIVAL BY DIAGNOSIS;OUTCOME IN ADULTS WHEN ECMO IS UNAVAILABLE;Results;;Gattinoni L. et al: patients;Gattinoni L. et al: outcomes;;Lower tidal volumes: patients;TV 6.2 + 0.8 vs. 11.8 + 0.8 ml/kg PIP 25 + 6 vs. 33 + 8 cm/H2O Mortality 31.0% vs. 39.8% (p=0.007) Days without organ failure also lower (p=0.006) ;Conclusions;5.7 patients per month !;Recruitment and enquiries Ann Truesdale, CESAR Trial Advisor;Patient recruitment;Recruitment;Recruitment and enquiries ;Participating centres (1);Participating centres (2);CESAR Collaborators;;;Bedford Hospital CCC – CESAR recruitment;Clinical Concerns;Role of Clinical Research Fellow.;CESAR Research Fellows;Concerns;Concerns (of some centres);; ;;Concerns (CAT team);Concerns (Data co-ordination centre) ;Any further concerns ?;We look forward to at least one patient from your centre in the next year.;Economics and the CESAR trial;Economics and the CESAR trial – economics researchers;CESAR economic evaluation Purpose and aims;CESAR trial - Primary hypothesis;A cost-effectiveness ‘decision plane’ for a new technology compared to current practice;CESAR economic evaluation Benefits of ECMO;Costs for the health service;Costs for patients and their supporters;Contribution of trial centres to the economic analysis;6 month follow up assessment;Primary Outcome;Secondary Outcomes;Instruments;Consent Options ;Pre-interview;Interview;Follow up rates September 04;Evidence-Based Care in ICUs;Research Priorities in UK;Randomised controlled trial AND (critical care OR intensive care);Evidence and ICU;Evidence and ICU;Evidence and ICU;Evidence and ICU;Evidence and ICU;Evidence