[自然科学]Chapter08反 合 成 分 析.docVIP

μú °? ?? ·′ o? 3é ·? ?? Retrosynthetic (or antithetic) analysis is a problem-solving technique for transforming the structure of a synthetic target (TGT) molecule to a sequence of progressively simpler structures along a pathway which ultimately leads to simple or commercially available starting materials for a chemical synthesis. The transformation of a molecule to a synthetic processor is accomplished by the application of a transform, the extract reverse of a synthetic reaction, to a target structure. E. J. Corey, 1989 ?ò ?? ò? Corey ×? 3? μ? ày ×ó1 ?a ày ?μ ?÷ ?? ?ù ′ó ?? ±ê ·? ×ó í? μ? o? 3é ?a ?￡ ′ó é? í? μ? ?? á? ·? ê?￡? ?ò ?? ?é ò? ·? ?? μ? μ? ò? ?μ áD μ? o? 3é ?a￡o a, C6H5 , b, C6H5CO, c, COOCH3 , d , C6H5COCHCOOCH3 , e, CH2CH2COOCH3 , f, CH-COOCH3 , g , CH2CH2CO, h , OCH3 μè?￡ ( CH2CH2COOCH3 í? μ? o? 3é ?a ′? ′a ê? ?a o? 3é éè ?? ?ù ó?￡? òò ′? ò? °? ?? ±? òa í? μ? 3? ?ù óD ?é ?ü μ? o? 3é ?a￡? ?ú é? ?? í? μ? 3? μ? o? 3é ?a ?D ?? ?? ?? óD d oí e ê? óD ?? ?μ μ??￡ óé d oí e ?′ ?é í? μ? μ? μ? ò× μ? μ? ê? ?á￡? ′? á? ê? ?á óé Michael ?ó 3é ?′ ?é μ? ?? ±ê ?ˉ o? ???￡ ?? ò? °? μ? o? 3é ?? ±ê ·? ×ó￡? ?a ?ó é? ê? ày ×ó ?? ?ù óé ·′ o? 3é ×a ?ˉ μ? μ? êμ ó? μ? o? 3é ?a￡? óD ?ú o? 3é ?ˉ ?§ ?ò ′ó o? 3é êμ ?ù ?D ò? ×ü ?á á? è? ?é 1? ?é2?￡ 8.1 ·′ o? 3é ×a ?ˉ μ? ?ù ±? í? ?? óD ?ú o? 3é μ? ?ù ′? ê? ?÷ ?? 1ù ?ü í? ?? ?? μ? ·′ ó|￡? òò ′? ·′ o? 3é μ? ?ù ±? í? ?? ò2 ê? ?§ è? ×? 1ù ?ü í? ?? ?? DD?￡ 8.1.1 μ￥ 1ù ?ü í? μ￥ ?ü ·? 2e ?a í¨ 3￡ ê1 ó? ?ú ×? ?ò μ￥ μ? 3? o?￡? ?÷ òa ê? ·? 2e C-X ?ü ?ò 1ù ?ü í? ?? ?ü μ? C-C ?ü?￡ è? ?? ?? μ? á? ?? ?é D?￡? ?° ?? ?ú ?ú ?￥ μ? ?￥ ?ü ′| ·? 2e￡? oó ?? ?ò ?? ?? ?ù áú ?? μ? C-C ?ü ?? á??￡ 8.1.2 μ￥ 1ù ?ü í? ?à ?ü ·? 2e ?a ò? àà μ? ·′ o? 3é ×a ?ˉ￡? ?? ?D ò? D? ò2 ?é 1é è? μ? 1ù ?ü í? ±? ?? ?? ?D￡? 3￡ ?? μ? óD 1, 1 1ù ?ü í?￡?1, 2 1ù ?ü í? oí 1, 4 1ù ?ü í? ·? 2e?￡ 1, 1 1ù ?ü í? ·? 2e ày è? ?? í? ?ù ê? μ? ?? ía￡? ?é ?? ?ü ·? 2e ?a ía oí ?t ′?￡? ?a ?1 ê? ?à μ± ?± 1? μ??￡ 1, 2 1ù ?ü í? ·?