[医药卫生]从治疗指南解读儿童癫痫的治疗.pptVIP

从主要治疗指南解读儿童癫痫的治疗;患病率（‰） 国外：3～10 我国：4～9 5岁以内起病者 50%;癫痫治疗的方法;抗癫痫药物治疗的主要目标;治疗目标的相对性;如何选择抗癫痫药物?;专家共识：全面性癫痫的治疗;专家共识：局灶性癫痫的治疗;癫痫药物治疗指南;Use monotherapy whenever possible. If the first treatment is unsuccessful, try monotherapy with another drug. If an AED has failed because of adverse effects or continued seizures, start the second drug (alternative firstline or second-line) and build up to an adequate or maximum-tolerated dose and only then taper off the first drug slowly. If the second drug is unhelpful, taper either the first or second drug (depending on relative efficacy, side effects and tolerability) before starting another drug. Consider combination therapy if seizures continue after attempts with monotherapy. If trials of combination therapy do not bring about worthwhile benefits, revert to the regimen (monotherapy or combination therapy) that has provided the best balance between tolerability and reducing seizure frequency.;单药治疗;第一个单药 47％无发作;单药治疗确实无效，可以多药联合治疗，以2～3种为宜 尽量联合应用抗痫机制不同的、具有药代动力学和药效学互补优势的、不良反应相互抵消或互不加重的AEDs ;Secondarily generalised;;癫痫药物选择指南：基于综合征类型  （ NICE guideline for children 2004 ）;ILAE Guidelines for Initial Monotherapy(ILAE2001);;Summary of AAN evidence-based guidelines level A or B recommendation;Treatment guidelines on epilepsy (AAN);FDA Indication Recommendation;CMA专家建议草案;CMA专家建议草案;CMA专家建议草案;CMA专家建议草案;;;ILAE 2006 Guidelines ;ILAE 2006 Guidelines for Initial Monotherapy;新诊断的部分性和全面性癫痫长期随机单药治疗的临床试验;青少年肌阵挛性癫痫 0 0 0 level A None level B None level C None;“The absence of rigorous comprehensive adverse effects data makes it impossible to develop an evidence-based guideline aimed at identifying the overall optimal recommended initial-monotherapy