滤泡树突细胞肉瘤序贯发生弥漫大B细胞淋巴瘤1例报道及-tumor.PDFVIP

768 　　肿瘤2014 年8 月第34 卷第8 期　TUM OR Vol. 34, August 2014 DOI: 10.3781/j .issn.1000-7431.2014.08.016 Copyright© 2014 by TUM OR Short Report 短篇报道 · 滤泡树突细胞 肉瘤序贯发生弥漫大B细胞淋巴瘤：1例报道及机制探讨 宾业鸿，蔡正文，刘汉峰 广西医科大学第一附属医院肿瘤内科，广西南宁 53002 1 [ 摘要 ]　本文报道1 例在滤泡树突细胞肉瘤基础上序贯发生弥漫大B 细胞淋巴瘤的罕见病例，并由此探讨滤泡树 突细胞肉瘤在弥漫大B 细胞淋巴瘤发生和发展中的可能作用。推测肿瘤组织微环境变化及肿瘤细胞转分化可能是 这种肿瘤转化发生的两种重要机制。 [ 关键词 ]　树突状细胞肉瘤，滤泡；淋巴瘤，大B 细胞，弥漫性；细胞转分化；肿瘤微环境 [中图分类号]　R733.4 [文献标志码] B [文章编号]　1000-7431 (2014) 08-0768-03 Sequential development of follicular dendritic cell sarcoma to diffuse large B-cell lymphoma: one case report and discussion on its possible mechanism BIN Ye-hong, CAI Zheng-wen, LIU Han-feng Department of Medical Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi Province, China [A BST RA CT]　This article reports a rare case of sequential development of follicular dendritic cell sarcoma (FDCS) to diffuse large B-cell lymphoma (DLBCL), and discusses the possible role of FDCS in facilitatinging genesis and development of DLBCL. It suggests that tumor microenvironment variation and transdifferentiation of tumor cells may be the two important mechanisms for this sequential development. [K EY W O R DS]　 Dendritic cell sarcoma, follicular; Lymphoma, large B-cell, diffuse; Cell transdifferentiation; Tumor microenvironment [ TUMOR , 2014, 34 (08): 768-770] 滤泡树突细胞肉瘤 （follicular dendritic cell sarcoma， 7.8 cm ×3.1 cm 。胸部CT 提示，胸骨后间隙有肿大淋巴结 FDCS）是一类具有滤泡树突细胞表型特征的肿瘤增殖性 影，大小约3.2 cm ×1.8 cm ；气管隆突后下方有肿大淋巴 疾病，病变主要累及淋巴结，另约有1/3 的病例发生在结 结，大小约2.0 cm ×1.5 cm 。不伴发热、盗汗及体质量减 外器官。由于滤泡树突细胞在