血尿酸水平与冠心病发病关系的剂量-反应Meta分析-中国循环杂志.PDFVIP

640 中国循环杂志 2016 年 7 月 第 31 卷 第 7 期（总第 217 期）Chinese Circulation Journal，July，2016，Vol. 31 No.7（Serial No.217） 冠心病研究 血尿酸水平与冠心病发病关系的剂量 - 反应 Meta 分析 芦永斌，程治远，赵亚学，常晓宇，程宁 摘要 目的：用 Meta 分析方法评价血尿酸水平与冠心病发病间的剂量 - 反应关系。 方法：通过数据库（PubMed, Elsevier 和 Web of Science）检索已经公开发表的国外关于血尿酸水平与冠心病发病的 队列研究。利用 Stata 软件对其进行综合分析。 结果：纳入 11 项队列研究，463 918 例研究对象。在男性和女性中，血尿酸水平增高均是冠心病发病的危险因素， 其相对危险度（RR）及其 95% 可信区间（95%CI）分别为：1.11（1.00~1.24）和 1.24（1.15~1.34）。剂量 - 反应 Meta 分析： 随着血尿酸水平的增加，冠心病发病风险也在逐步增加；血尿酸水平每增加 1mg/dl，在男性和女性中冠心病发病风险 分别增加 4.8% 和 12.4%，且女性明显高于男性。 结论：血尿酸水平与冠心病发病存在密切相关。 关键词 尿酸；冠状动脉疾病 Meta Analysis for the Relationship Between the Levels of Serum Uric Acid and Prevalence of Coronary Artery Disease LU Yong-bin, CHENG Zhi-yuan, ZHAO Ya-xue, CHANG Xiao-yu, CHENG Ning. Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou (730000), Gansu, China Corresponding Author: CHENG Ning, Email:chengn@lzu.edu.cn Abstract Objective: To evaluate the relationship between the levels of serum uric acid (SUA) and prevalence of coronary artery disease (CAD) by Meta analysis. Methods: We searched the databases of Pub Med, Elsevier and Web of Science for internationally published cohort study for the relationship between SUA levels and CAD prevalence and conducted a general analysisby using Stata software. Results: A total of 11 cohort study including 463,918 subjects were enrolled in this study. For both male and female genders, increase SUA level was the risk factor for CAD occurrence (RR=1.11, 95% CI 1.00-1.24) and (RR=1.24, 95% CI 1.15-1.34). Dose-response Meta-analysis indicated that by 1 mg/dl SUA elevation, the risk of CAD occurrence would increase 4.8% in male and 12.4% in female, the risk in female gender was higher than male. Co