egfr与vegf在三阴性乳腺癌中的表达及意义.docVIP

EGFR与VEGF在三阴性乳腺癌中的表达及意义 　　[摘要] 目的 探讨表皮生长因子受体（EGFR）与血管内皮生长因子（VEGF）在三阴性乳腺癌中的表达及临床意义。方法 选择2014年1月～2016年12月在我院手术切除的三阴性乳腺癌标本52例为观察组，另选择同期在我院手术治疗的非特殊类型乳腺浸润性导管癌标本50例为对照组。检测两组标本中EGFR与VEGF的阳性率，分析三阴性乳腺癌患者的年龄、临床分期、淋巴?Y转移、肿瘤大小等与EGFR及VEGF阳性率的关系。 结果 观察组VEGF阳性率、EGFR阳性率均显著高于对照组，差异有统计学意义（P0.05）；临床分期Ⅲ-Ⅳ期的EGFR阳性率显著高于Ⅰ-Ⅱ期，差异有统计学意义（P0.05）；有淋巴结转移组织的VEGF阳性率显著高于无淋巴结转移组织，差异有统计学意义（P 　　[关键词] 表皮生长因子受体；血管内皮生长因子；三阴性乳腺癌；表达 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1673-9701（2017）14-0032-03 　　[Abstract] Objective To investigate the expression and clinical significance of EGFR and VEGF in triple negative breast cancer. Methods A total of 52 cases of triple-negative breast cancer specimen surgically resected in our hospital from January 2014 to December 2016 were selected as the observation group， and 50 cases of non-special type breast invasive ductal carcinoma specimen surgically resected in our hospital in the same period were chosen as the control group. The positive rates of EGFR and VEGF in the two groups were detected. The relationship between the age， clinical stage， lymph node metastasis， tumor size and the positive rate of EGFR and VEGF was analyzed in triple negative breast cancer patients. Results The positive rate of VEGF and the positive rate of EGFR in the observation group were significantly higher than those in the control group（P0.05）. The positive rate of EGFR in clinical stage Ⅲ-Ⅳ was significantly higher than that in stage Ⅰ-Ⅱ， and the difference was statistically significant（P0.05）. The positive rate of VEGF in patients with lymph node metastasis was significantly higher than that in patients without lymph node metastasis， and the difference was statistically significant（P 　　三阴性乳腺癌是指癌组织免疫组织化学检查结果为雌激素受体（ER）、孕激素受体（PR）和原癌基因Her-2均为阴性的乳腺癌，占所有乳腺癌病理类型的10.0%～20.8%，具有特殊的生物学行为和临床病理特征，预后较其他类型差[1，2]。表皮生长因子受体（epidermal growth factor receptor，EGFR）是表皮生长因子受体（HER）家族成员之一，该家族包括HER1（erbB1，EGFR）、HER2（erbB2，NEU）、HER3（erbB3）及HER4（erbB4）。HER家族在细胞生理过程中发挥重要的调节作用[3，4]。血管内皮生长因子（vascular endothelial growth f