轻度认知障碍患者血清胆固醇及β-淀粉样蛋白水平检测的相关性研究.docVIP

精品论文 参考文献 轻度认知障碍患者血清胆固醇及β-淀粉样蛋白水平检测的相关性研究 （陕西省延安大学附属医院检验科 陕西 延安 716000） 【摘 要】目的：研究轻度认知障碍(MCI )患者血清中胆固醇和beta;-淀粉样蛋白的含量。方法：采用双抗体夹心酶联免疫吸附法检测42例MCI患者，37例老年性痴呆(AD) 患者，45例健康者血清中胆固醇和beta;-淀粉样蛋白水平。结果：MCI组血清中Abeta;1-42蛋白浓度与对照组、AD组比较有升高趋势，Plt;0.05。MCI组患者血清中的总胆固醇与对照组比较明显升高，差异有统计学意义Plt;0.05。对照组患者血清中的Abeta;1-42蛋白的浓度与AD组比较差异有统计学意义Plt;0.05结论：MCI患者血清中胆固醇和beta;-淀粉样蛋白水平与疾病的发展相关。 【关键词】认知障碍；阿尔茨海默病；beta;-淀粉样蛋白；胆固醇 【中图分类号】R749.16 【文献标识码】A 【文章编号】1004-6194（2015）02-0055-02 A study of the correlation between serum cholesterol and beta amyloid protein levels in patients with mild cognitive impairment Affiliated Hospital of Yanan University of Shaanxi Province inspection department Bai Lifen zip code 716000 【Abstract】Objective:To study the contents of cholesterol and beta amyloid in serum of patients with mild cognitive impairment (MCI).. Methods: double antibody sandwich ELISA was used to detect 42 patients with MCI, 37 patients with senile dementia (AD), 45 healthy persons with serum cholesterol and beta amyloid protein level. Results: the concentrations of A 1-42 in serum of MCI group were increased compared with control and AD, and Plt;0.05. The total cholesterol in serum of MCI group was significantly higher than that in control group, and the difference was statistically significant Plt;0.05. Control group in serum of patients with the beta amyloid protein concentration and ad group difference was statistically significant (P lt; 0.05) conclusion: the development of MCI in serum of patients with cholesterol and beta amyloid protein levels and disease. 【Keywords】cognitive impairment Alzheimer disease beta amyloid protein cholesterol 阿尔茨海默病( Alzheimers disease，AD) 是人类最常见的神经退行性疾病，是老年期痴呆的主要病因〔1〕，其特征性病理表现是神经元纤维缠结( Neurofibrillary tangles，NFT) 、老年斑( Senile Plaque，SP)和神经元细胞丢失等〔2〕。大量研究表明高胆固醇饮食与AD 发生密切相关，高胆固醇血症能够促进淀粉样前体蛋白代谢，加剧beta;-淀粉样蛋白沉积，进而形成老年斑导致AD 发生〔3〕，但有关高胆固醇血症与AD 发病过程中NFT 形成间的研究少有报道。轻度认知障碍(mlonteipimetMC)idcgivmarn，MCI）是介于正常老化与痴呆之间的一种过渡状态_l。随着研究的深入。人们发现M