肌酸激酶及同工酶与急性百草枯中毒程度关系的临床研究.docVIP

精品论文 参考文献 肌酸激酶及同工酶与急性百草枯中毒程度关系的临床研究 杨荣金 华平锋 李琼玉 宋李梅 （邛崃市医疗中心医院 四川 成都 611530） 【摘要】目的：研究肌酸激酶和同工酶以及二者的比值与百草枯中毒程度的关系，为百草枯中毒临床治疗及预后判断提供参考依据。方法：把52 例急性百草枯中毒患者分为存活组及死亡组，与52 例正常对照组进行心肌酶谱测定, 用美国Beckman Cx7 全自动生化分析仪，测定患者入院即刻、24h、48h、72h、96h 空腹静脉血CK、CK-MB，计算CK ／ CK-MB 比值，根据正常对照组和中毒存活组、中毒死亡组测定结果进行比较；用SPSS ／ DE 软件分别行方差分析和q 检验统计分析。结果：CK、CK-MB、CK ∕ CK-MB 中毒组高于对照组，且中毒程度越重，CK、CK-MB、CK ∕ CK-MB 比值增高越明显，死亡组明显高于存活组(Plt;0．01)。结论：测定CK、CK-MB、CK ／ CK － MB 比值能够反映急性百草枯中毒程度，可作为急性百草枯中毒患者临床分级和判定病情轻重及预后的可靠指标，据其中毒程度制定适宜治疗方案。 【关键词】肌酸激酶 同工酶 百草枯中毒 【中图分类号】 R2 【文献标号】 A 【文章编号】 2095-7165（2015）07-0066-02 Creatine kinase and its isoenzyme and clinical study on the relationship between acute paraquat poisoningYang Rongjin，Hua Pingfeng，Li Qiongyu，Song Limei(Qionglai City Medical Center Hospital, 611530, Chengdu, Sichuan) 【Abstract 】Objective: To study the relationship between creatine kinase isoenzyme and paraquat poisoning as well as the ratioof the two levels, for paraquat poisoning, clinical treatment and prognosis provide references. Methods: 52 cases of acute paraquatpoisoning and death survival group were divided into groups, with 52 cases of myocardial enzymes were measured in normal controlgroup, with the United States Beckman Cx7 automatic biochemical analyzer to measure the patient hospitalized immediately, 24h, 48h,72h , 96h fasting blood CK, CK-MB, calculate CK / CK-MB ratio were compared according to the normal control group and poisoningsurvival group, the measurement results poisoned group; using SPSS / DE software analysis of variance were performed statisticalanalysis and q test . Results: CK, CK-MB, CK / CK-MB poisoning group was higher, and the more severe the degree of intoxication, CK,CK-MB, CK / CK-MB ratio increased more significantly, the death was significantly higher than the survival group ( P lt;0.01). Conclusion:Determination of CK, CK-MB, CK / CK-MB ratio reflects the degree of acute paraquat poisoning, can be used as clinical cla