蛋白质赖氨酸乙酰化修饰对中间代谢的调控研究.PDFVIP

中国生物工程杂志 ChinaBiotechnology 蛋白质赖氨酸乙酰化修饰对中间代谢的调 控研究 1 ** 赖木兰 陈雪岚 (江西师范大学生命科学学院 南昌 330022) 摘要：生命活动的中间代谢酶存在大量的赖氨酸乙酰化修饰作用，这些在特定位点进行可逆 的赖氨酸乙酰化修饰作用能精确地调控胞内各种代谢路径。因此，对中间代谢酶赖氨酸乙酰 化的研究成为了当今热点。本文综述了中间代谢酶的乙酰化修饰的研究进展，并归纳了几种 典型的中间代谢酶的可逆乙酰化作用及其乙酰化位点的分布和在中间代谢路径中重要的调 1 控作用, 以期为深入研究蛋白质乙酰化修饰提供参考。 v 3 关键词：赖氨酸乙酰化 中间代谢酶 调控 乙酰化转移酶 脱乙酰化酶 9 6 Devolopment ofregulationofprotein lysine acetylation on 0 intermediate metabolism 0 . 1 ** 7 LAI Mu-lan CHEN Xie-lan 0 7 （College of Life Sciences, JiangXi Normal University, Nan Chang 330022, China ） 1 Abstract: A large number of lysine acetylation exist in the intermediate metabolic enzymes of 0 2 life activities.Thereversible lysine acetylation at specific sites ofprotein can regultevariouskinds : v of intracellula metabolic pathways. Thus, the research of lysine acetylation of intermediate i X a metabolic enzymescurrently becomes ahotspot.Thepaperreviewstheresearch progress oflysine n acetylation of intermediate metabolic enzymes and summarizes several typical reversible lysine i h acetylation ofintermediatemetabolic enzymes,their distribution sites andthe important regulatory c role in the intermediate metabolic pathways,which provide a reference for futher study ofprotein acetylation. Key words: lysine actylation; intermediate metabolic enzymes; regulation; acetyltransferase; d