慢性呼吸衰竭合并肺性脑病早期药物诊治的体会黄远茂.docVIP

精品论文 参考文献 慢性呼吸衰竭合并肺性脑病早期药物诊治的体会黄远茂 武汉市黄陂区武湖街道卫生院 湖北武汉 430300 摘要：目的：观察慢性呼吸衰竭合并肺性脑病早期药物诊治的临床疗效，及探讨其可能的作用机理和其不良反应。方法：选取2014年3月- 2015年11月来我院呼吸内科就诊慢性呼吸衰竭合并肺性脑病患者60例，随机分为实验组和对照组，各30例，在常规治疗基础之上，实验组给予纳洛酮治疗，对照组给予普通氧疗、纠正酸碱电解质等常规治疗。比较两组治疗前、后动脉血氧分压、心率、呼吸频率等变化及不良反应情况。结果：治疗48h后，实验组有效率为90%，对照组有效率为73.33%，差异具有统计学意义（plt;0.05）；实验组头晕1例，恶心2例，心动过速l例；对照组头晕2例，恶心2例，心动过速0例，两组不良反应差异无统计学意义（pgt;0.05）。结论：早期应用纳洛酮治疗慢性呼吸衰竭合并肺性脑病较常规氧疗显著，改善低氧血症，副作用较少，可提高呼吸衰竭患者生活质量，值得临床推广应用。 关键词：呼吸衰竭；肺性脑病；纳洛酮；临床疗效 Abstract Objective：To observe the clinical effect of early diagnosis and treatment of chronic respiratory failure with pulmonary encephalopathy，and to investigate its possible mechanism and adverse reactions.Methods：60 cases of chronic respiratory failure complicated with pulmonary encephalopathy were randomly divided into experimental group and control group，each of 30 cases.The experimental group was treated with naloxone，and the control group was treated with conventional therapy，and the control group was treated with conventional therapy.The changes of blood pressure，heart rate，respiratory rate and adverse reactions of two groups before and after treatment were compared.Results：after treatment，the effective rate was 90% in treatment group and 73.33% in control group（plt;0.05），1 cases in experimental group，2 cases of nausea，2 cases of control group，0 cases of nausea，two cases of adverse reaction（pgt;0.05）.Conclusion：early application of naloxone in the treatment of chronic respiratory failure with pulmonary encephalopathy，compared with conventional oxygen therapy，improve hypoxia，less side effects，can improve the quality of life in patients with respiratory failure，it is worthy of clinical application. [Keywords]respiratory failure；pulmonary encephalopathy；naloxone；clinical efficacy 慢性呼吸衰竭是呼吸内科常见病、多发病，也是一急危重症，死亡率较高，可并发多种严重并发症其中肺性脑病是比较严重且常见的并发症。肺性脑病的实质上是二氧化碳潴留体内所致的中枢神经系统麻醉[1]，该病是以神经精神症状为主要表现的临床综合征，假如治疗不当或不及时死亡率较高。为进一步提高慢性呼吸衰竭合并肺性脑病的临床治疗效果，本研究将纳洛酮早期应用于治疗慢性呼吸衰竭合并肺性脑病，效果较好且不良反应较少