血友病与ITP.pptVIP

Hemophilia It is caused by a defect in the genes that determine clotting factors Ⅷ, Ⅸ and Ⅺ, named as hemophilia A,B and factor Ⅺ deficiency(C), respectively. Hemorrhage is basic manifestation since the disorder of thromboplastin generation.; A B FⅪ deficiency factor of ↓ Ⅷ Ⅸ Ⅺ Place of gene X X autosome Inheritance sex-linkage autosome recessive recessive Sex M M F＞M Rate(%) 85 12 3 ;Inheritance of Hemophilia A or B“Carriar Mother and Father Without Hemophilia”;Inheritance of Hemophilia A or B Father with Hemophilia And mother who is not a “Carrier” A man with hemophilia cannot pass the disorder on to his sons. All of his daughters, however, will be “carriers”.; Health Cariier Hemophilia Hemophilia XY XX XY XX;● Bleeding can occur in many joints, the most of them are: Knees Elbows Ankles ● Repeated bleeding can lead to degeneration of cartilage and bone, cause chronic joint stiffness and pain ;Bleeding in the soft tissue and muscles;joint stiffness in hemophilia;Injection hematoma in hemophilia; 3. Clinical type of hemophilia Type Content of Ⅷ or Ⅸ C.ofⅪ (%) (u/ml) Subclinical 25-45 0.25-0.45 Mild ＞5–25 0.05-0.25 Moderate 1–5 0.01-0.05 Severe ≤ 1 ≤ 0.01 Heterozygote ＞20% Homozygote ＜2%; Type and Bleeding of hemophilia A B Type Bleeding C.of F(%) Subclin