有机化学讲义（上海有机所）-07 复杂分子的多样性问题.pdf

第八部分 第八部分 复杂分子的多样性问题 复杂分子的多样性问题 Combinatorial Chemistry Combinatorial Chemistry Natural Product-Like Chemistry Natural Product-Like Chemistry Combinatorial Chemistry: Reviews 1. A Practical Guide to Combinatorial Chemistry ；Czarnik, A. W. and DeWitt, S. H., Eds.; ACS: Washington DC, 1997. 2. Molecular Diversity and Combinatorial Chemistry: Library and Drug Discovery ; Chaiken, I. N., Janda, K. D., Eds.; ACS: Washington DC, 1996. 3. Balkenhol, F., et al. Combinatorial Synthesis of Small Molecules. Angew. Chem. Int. Ed. Engl. 1996, 35, 2288. 4. Ellman, J. A., et al. Synthesis of Small Molecule Libraries. Chem. Rev. 1996, 96, 555. 5. Gallop, M. A., et al. Applications of Combinatorial Technologies to Drug Discovery, 1. Background and Peptide Combinatorial Libraries. J. Med. Chem. 1994, 37, 1233. 6. Gordon, E. M., et al. Applications of Combinatorial Technologies to Drug Discovery, 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions. J. Med. Chem. 1994, 37, 1385. Solid Phase Peptide Synthesis (SPPS) Cl R1 O •Attach 1st Amino Acid to NHCbz (Chloromethylated) Polymer O R1 O bead O NHCbz N •Deprotect (HBr), Couple H O R2 (DCC), Cap (acetic anhydride) R1 O R3 O H O N NHCbz