吡拉西坦治疗创伤性脑水肿62例疗效观察.docVIP

精品论文 参考文献 吡拉西坦治疗创伤性脑水肿62例疗效观察 丁绪元 刘大军 钱中琪（江苏省泰州市第二人民医院神经外科 225500） 【摘要】目的：观察吡拉西坦注射液治疗创伤性脑水肿的临床效果。方法：将我院近一年收治的62例创伤性脑水肿患者62例随机分为对照组和治疗组，其中：治疗组31例，静滴20%吡拉西坦注射液治疗；对照组31例，静滴20%甘露醇治疗。通过患者的头痛、呕吐症状，意识状态的变化，视乳头水肿以及头颅CT水肿带的好转等，观察药物的疗效。通过测定两组治疗前后肾功能以及血电解质的变化，观察药物的副作用。结果：治疗组显效4例，有效24例，无效2例；对照组显效5例，有效22例，无效3例.两组的总有效率分别为93.33%和90.00%，无显著性差异(Pgt;0.05)。在用药期间和用药后治疗组没有观察到与所用药品有关的副作用，对照组有一例用药5天后出现甘露醇肾病。结论：吡拉西坦注射液治疗创伤性脑水肿疗效肯定且安全，值得临床推广。 【关键词】吡拉西坦注射液 颅脑损伤 脑水肿 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2013）26-0155-02 Observation on Curative Effect of Piracetam Injection in Patients with traumatic brain edema 62 cases DING Xu-yuan LIU Da-jun QIANA Zhong-qi (Department of Neurosurgery,The Second Peoples Hospital of Taizhou,Taizhou 225500,china) 【Abstract】Objective :To investigate the effect of piracetam injection on reduction the traumatic brain edema. Methods:62 patients with traumatic encephaledemal were divided into the treatment group and the control group,31 cases were injected by the 20% piracetam injection,the other 31 cases were injected by the 20% mannitol..Observing the manifestation including headach,vomit,consciousness,papilledma and encephaledema of cranial CT,Determining the change of renal function and electrolyte in blood.Results: The total effective rate of two group was 93.33% and 90.00%,no significant diffevence(Pgt;0.05).No adverse reactions was observed in the treatment group during and after treatment.One case appeared with Mannitol renal disease in the control group after medicine for five days.Conclusion:The effect of piracetam injection on reduction the traumatic brain edema is safe and rehable,it was worthy of clinical promotion. 【Key words】Peracetam Injection ceraniocerebral Cerebral edema 吡拉西坦在临床上使用多年，有很多关于治疗脑水肿方面的报道，我院从2011年开始使用此药，急性创伤性脑水肿是影响颅脑外伤预后的主要因素，临床上如处理即时、得当，可以明显改善颅脑外伤患者的预后。总结如下。 1 对象和方法 1.1对象 我科2011年10月-2012年10月收治的急性颅脑外伤患者，GCSgt;8分，头颅CT提示血肿量lt;30m1,CT证实的脑挫伤患者，眼底检查有视乳头水肿