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e-vpalwuaitionofthepathologicalgradeingliomasapplicationofdsc.doc

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e-vpalwuaitionofthepathologicalgradeingliomasapplicationofdsc

精品论文 参考文献 E-vPalWuaItionofthePathologicalGradeinGliomasApplicationofDSC WangYing1 QIJianping2 1,2 DepartmentofRadiology,TonjiHospital,Tongji MedicalCollegeof Huazhong UniversityofScienceand Technology,WuGhan430032,China;1DepartmentofRadiology,WuhangeneralhospitalofGuangzhoucommand,Wuhan430070,ChinaCommunicationauthor:QIJianping,Email:qijp2k01@163.comFinancialsupport is from Natural Science Foundation in Chinarsquo;s Hubei provincial science and technology program (Numbered2012FFB06809)【Abstract】objective AssessmentofDSC-PWIforgliomaspreoperativevalueofhistologicalgrade.MaterialsandMethods 76casesgliomasconfirmedbysurgeryandpathologywereanalyzed,36casesof low-grade(gradeI~II),40casesof high-grade(gradeIII~IV),allcasesunderwentconventionalMRIplanescan,contrastMRIscanandDSC-PWI.MaximumrCBVvaluesofsolidpart(thesolidparttothecorrespondingcontralateralnormalwhitematterratio)arecacuGlated.ComparisonofmaximumrCBVvaluesoftumordifferentlevelswasassessedbyttest.DrawingROCcurvetodeterminetheidealvalueofrCBVthresholdbeGtweenhigh-gradeandlow-gradegliomas.Results ThemaximumvalueofrCBVinthesolidpartofgliomasarerelatedpositivelywithpathologicallevels,themaximumrCBVvaluesofhigh-gradeandlow-gradegliomaswere0.8744plusmn;0.935、2.0415plusmn;1.5311respectively,significantdifferencewereshowedamongallgradesofgliomas(P=0.002).Toidentifythehighlevelandlow-gradegliomas,1.35astheidealthreshold,theAUCvalue0.7394,thesensitivityandspecificitywere66.7%,73.0%.Conclusion rCBVexaminationwillbeabletoassesstheleveloftumorpathology.PWIexaminationforpreoperativeevaluationofgliomashavea【Kheiyghweorrdvsal】ueofhistologicalgrade. glioma;DSC-PWI;rCBV 【中图分类号】R47 【文献标识码】B   【文章编号】1008-6315(2015)12-1279-02  Ingliomapathologicaldiagnosis,themicrovesseldensityoftumorisoneofmain standards for evaluation of pathological grade [1,2].Present,mostresearchesshowthatCBVisthemostvaluableparameterforevaluationofpaGthologygrading.Therestparametershavelimitedvalue,thecorrelationofwhichwithgliomapathologygradingisnrsquo;

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