乙基-恶唑啉-药学学报.PDFVIP

聚（2-乙基-2-噁唑啉）在药物递送系统中的应用 毛娟，李建明，丁劲松* ( 中南大学湘雅药学院，湖南 长沙410013) 摘要：聚(2-乙基-2-噁唑啉) [poly(2-ethyl-2-oxazoline), PEOz] 是一种由2- 乙 基-2-噁唑啉通过阳离子开环聚合得到的亲水性长链聚合物，具有低毒、生物相 容性及分子链柔性好、易于修饰的特性。将其用于药物或载药系统的修饰可使后 者具有长循环能力，而不表现出聚乙二醇（polyethylene glycol，PEG ）修饰的抑 制靶细胞摄取、妨 pH 敏感纳米粒 “核内体逃逸”等缺点，是一种潜在的PEG 替代物。本文综述了PEOz 的理化性质、合成方法及其在药物递送系统中的应用。 关键词：聚(2- 乙基-2-噁唑啉)；聚乙二醇；pH-敏感；温敏；药物递送系统 中图分类号: R943 文献标识码: A 文章编号: 0513-4870 （2017） The application of poly(2-ethyl-2-oxazoline) in drug delivery system * MAO Juan, LI Jian-ming, DING Jing-song (School of Xiangya Pharmaceutical Sciences, Central South University, Changsha 410013, China) Abstract : Poly(2-ethyl-2-oxazoline) (PEOz), a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline, has the characteristics of low toxicity, biocompatibility, flexible chain, and modified expediently. PEOz is a potential substitutes of polyethylene glycol (PEG) to render the ability of long-circulation, enhanced cellular uptake and endosomal escape behaviors to PEOz modified drug delivery system. In this review, the research progress of physicochemical properties, synthetic methods and the application of PEOz in drug delivery system are summarized. Key words: poly(2-ethyl-2-oxazoline); polyethylene glycol; pH-sensitive; thermosensitive; drug delivery system 在药物及给药系统表面修饰聚乙二醇（polyethylene glycol，PEG ）是延长其 [1] 在体循环时间，增加药物生物利用度的常用方法 。但 PEG 修饰具有抑制纳米 收稿日期: 2017-2- 17; 修回日期: 2017-3-30. 基金项目：国家自然科学基金资助项目 ）. *通讯作者 Tel: 86-731 E-mail: dingjs 0221@163.com