中文摘要-淡江大学机构典藏.PDFVIP

中文摘要 本研究以浸漬相轉換法製備生物可分解性高分子－聚丁基烷酯 (Poly(hydroxybutyrate ；PHB)之多孔型薄膜，並應用電漿誘導接枝將薄膜表面改 質使薄膜表面功能化。PHB 薄膜之製備以氯仿為溶劑，乙醇為非溶劑。首先製作 ethanol －chloroform －PHB 成膜系統之相圖，利用其選定適當製膜液組成，並藉 由改變製膜液之配製溫度，製備不同結構之薄膜。薄膜之孔隙結構、結晶性、機 械強度、滲水性等皆加以分析探討，以了解這些物性與製膜程序之關係。其次我 們以電漿誘導聚合法將聚丙烯酸接枝在 PHB 薄膜表面上，並藉由改變接枝條件 如電漿處理時間、電漿功率、接枝反應時間、單體濃度等獲取最佳接枝條件，結 果顯示最大接枝量可達 0.48/cm2 。下年度計畫我們將利用 1-ethyl-3-(3-diethylaminopropyl) carbodiimide hydrochloride (EDC) 使離胺酸與丙 烯酸反應形成醯胺鍵，而將離胺酸固定於薄膜上，以探討其對骨母細胞貼附及生 長之影響，利用PHB 之生物分解性，開發新型生醫膜材。 關鍵字：生物可分解性高分子，聚丁基烷酯，多孔型薄膜，電漿表面改質 1 Abstract In this research, porous membranes of a biodegradable polymer, poly(hydroxybutyrate), were synthesized and the surfaces of which were modified by plasma-induced polymerization so as to engender functionality to the membranes. Chloroform and ethanol were used as the solvent and nonsolvents, respectively, for membrane formation by the immersion precipitation method. Phase diagram of the ethanol-chloroform-PHB system was constructed; thereby appropriate dope composition was selected. Membranes with different structures were then prepared by changing the dope preparation temperature. The porous structure, crystalline character, mechanical strength, and water wettibility of the formed membranes were studied to understand the relationship between these properties and the membrane formation process. Plasma-induced polymerization method was employed to graft poly(acrylic acid) on the membrane surface. Various variables, viz., plasma treatment time, plasma power, grating reaction time, and monomer concentration were investigated and the largest grafting yield was found to be 0.48 mg/cm2 under optimal conditions. For the next year, lysine will be immobilize