NDRG1及E-cadherin蛋白表达及大肠癌侵袭转移关系及其意义.docVIP

NDRG1及E-cadherin蛋白表达及大肠癌侵袭转移关系及其意义 　【摘要】 目的：探讨NDRG1和E-cadherin蛋白在大肠癌组织中的表达、相互关系及临床意义。方法：应用免疫组织化学（SP）法检测12例正常大肠组织、58例大肠癌组织中NDRG1和E-cadherin蛋白的表达情况。应用χ2检验对两者与临床病理因素关系进行统计分析，两者表达间的相关性采用spearman等级相关检验。结果：正常大肠组织和大肠癌组织中NDRG1阳性表达率分别为75.00%（9/12）和51.72%（30/58），E-cadherin阳性表达率分别为91.67%（11/12）和55.17%（32/58）。NDRG1和E-cadherin在大肠癌组织中阳性表达率均低于正常大肠组织阳性表达率。NDRG1和E-cadherin的表达与大肠癌的Dukes分期、淋巴结转移、肝转移显著相关（Plt;0.05）。E-cadherin的异常表达与肿瘤的分化程度显著相关（Plt;0.05）。大肠癌组织中NDRG1和E-cadherin蛋白的表达呈正相关（Plt;0.05）。结论：大肠癌组织中NDRG1和E-cadherin蛋白表达状况有助于判断大肠癌生物行为及恶性程度。NDRG1和E-cadherin联合检测，可能成为预测大肠癌肝转移的有效手段。 【关键词】 大肠肿瘤·NDRG1·E-cadherin Expression of NDRG1 and E-cadherin in infestation and metastatic about colorectal cancer 【ABSTRACT】Objective: To investigate the expression of NDRG1 and E-cadherin protein in the colorectal cancer. Methods: The expression of NDRG1 and E-cadherin protein was detected by SP immunohistochemical method in 12 normal colorectal tissues and 58 colorectal cancer. χ2 test and spearman exam were used for statistical analysis. Results: The positive expression rates of NDRG1 were 75.00%（9/12） and 51.72%（30/58） in normal colorectal tissue and colorectal cancer respectively, the positive expression rates of E-cadherin were 91.67%（11/12） and 55.17%（32/58） in normal colorectal tissue and colorectal cancer respectively. Both the positive rates of NDRG1 and E-cadherin protein expressed in the colorectal cancer were lower than those expressed in the normal colorectal tissue. The expression of NDRG1 and E-cadherin was related to the Dukes stage, lymph node metastasis and liver metastasis of colorectal cancer significantly （Plt;0.05）. The abnormal expression of E-cadherin was also related to the differentiation of the tumor significantly （Plt;0.05）. The expression of NDRG1 and E-cadherin was positively related in colorectal cancer （Plt;0.05）. Conclusion: The low expression of NDRG1 and E-cadherin protein was related to the infiltration, metasta 　　大肠癌是临床最常见的肿瘤之一，近年来其发病率逐渐增加［1］，发病年龄也趋向年轻化，发病部位趋向近侧结肠。有