delayed appearance of high altitude retinal hemorrhages延迟高海拔视网膜出血.pdfVIP

Delayed Appearance of High Altitude Retinal Hemorrhages 1. 1 . 2 3 3 Daniel Barthelmes , Martina M. Bosch * , Tobias M. Merz , Benno L. Petrig , Frederic Truffer , Konrad E. 4,5 1 6 7 1 1 Bloch , Timothy A. Holmes , Philippe Cattin , Urs Hefti , Miriam Sellner , Florian K. P. Sutter , Marco Maggiorini8, Klara Landau1 1 Department of Ophthalmology, University Hospital Zurich, Zurich, Switzerland, 2 Department of Intensive Care Medicine, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland, 3 Institut de Recherche en Ophtalmologie, Sion, Switzerland, 4 Pulmonary Division, University Hospital Zurich, Zurich, Switzerland, 5 Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, 6 Medical Image Analysis Center (MIAC), University of Basel Faculty of Medicine, Basel, Switzerland, 7 Department of Surgery, State Hospital Liestal, Liestal, Switzerland, 8 Medical Intensive Care Unit, University Hospital Zurich, Zurich, Switzerland Abstract Background: Retinal hemorrhages have been described as a component of high altitude retinopathy (HAR) in association with altitude illness. In this prospective high altitude study, we aimed to gain new insights into the pathophysiology of HAR and explored whether HAR could be a valid early indicator of altitude illness. Methodology/Principal Findings: 28 mountaineers were randomly assigned to two ascent profiles during a research expedition to Mt. Muztagh Ata (7546 m/24,751 ft). Digital fundus photographs were taken prior to expedition at 490 m (1,607 ft), during expedition at 4