deep sequencing of antiviral t-cell responses to hcmv and ebv in humans reveals a stable repertoire that is maintained for many years深度测序的抗病毒t细胞反应和ebv血巨细胞病毒在人类揭示了一个稳定的曲目,是多年来维护的.pdfVIP

下载本文档

4
0
约6.03万字
约 9页
2017-09-12 发布于上海
举报
版权申诉

deep sequencing of antiviral t-cell responses to hcmv and ebv in humans reveals a stable repertoire that is maintained for many years深度测序的抗病毒t细胞反应和ebv血巨细胞病毒在人类揭示了一个稳定的曲目,是多年来维护的.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

deep sequencing of antiviral t-cell responses to hcmv and ebv in humans reveals a stable repertoire that is maintained for many years深度测序的抗病毒t细胞反应和ebv血巨细胞病毒在人类揭示了一个稳定的曲目,是多年来维护的

Deep Sequencing of Antiviral T-Cell Responses to HCMV and EBV in Humans Reveals a Stable Repertoire That Is Maintained for Many Years P. L. Klarenbeek1,2,3., E. B. M. Remmerswaal3,4., I. J. M. ten Berge3,4, M. E. Doorenspleet1,2,3, B. D. C. van 5 1,2,3 3 6 5 4 1 Schaik , R. E. E. Esveldt , S. D. Koch , A. ten Brinke , A. H. C. van Kampen , F. J. Bemelman , P. P. Tak , 2 1 3,6 F. Baas , N. de Vries , R. A. W. van Lier * 1 Department of Clinical Immunology Rheumatology, Academic Medical Center, Amsterdam, the Netherlands, 2 Department of Genome Analysis, Academic Medical Center, Amsterdam, the Netherlands, 3 Department of Experimental Immunology, Academic Medical Center, Amsterdam, the Netherlands, 4 Renal Transplant Unit, Academic Medical Center, Amsterdam, the Netherlands, 5 Bioinformatics Laboratory, Academic Medical Center, Amsterdam, the Netherlands, 6 Sanquin Research at CLB and Landsteiner Laboratory, Amsterdam, the Netherlands Abstract CD8+ T-cell responses against latent viruses can cover considerable portions of the CD8+ T-cell compartment for many decades, yet their initiation and maintenance remains poorly characterized in humans. A key question is whether the clonal repertoire that is raised during the initial antiviral response can be maintained over these long periods. To investigate this we combined next-generation sequencing of the T-cell receptor repertoire with tetramer-sorting to identify, quantify and longitudinally follow virus-specific clones within the CD8+ T-cell compartment. Using this approach we studied primary infections of human cytomegalovirus (hCMV) and Epstein Barr virus (EB