crosstalk between nuclear factor i-c and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis核转录因子之间的串扰我和转变增长factor-β1信号调节成牙质细胞分化和体内平衡.pdfVIP
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crosstalk between nuclear factor i-c and transforming growth factor-β1 signaling regulates odontoblast differentiation and homeostasis核转录因子之间的串扰我和转变增长factor-β1信号调节成牙质细胞分化和体内平衡
Crosstalk between Nuclear Factor I-C and Transforming Growth Factor-b1 Signaling Regulates Odontoblast Differentiation and Homeostasis 1 2 3 4 5 Dong-Seol Lee , Won-Joon Yoon , Eui Sic Cho , Heung-Joong Kim , Richard M. Gronostajski , Moon-Il 6 1 Cho , Joo-Cheol Park * 1 Department of Oral Histology-Developmental Biology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea, 2 Department of Molecular Genetics, BK21 Project, School of Dentistry, Seoul National University, Seoul, Korea, 3 Laboratory for Craniofacial Biology, Institute of Oral Bioscience, Chonbuk National University, Jeon-ju, Korea, 4 Department of Oral Anatomy and Developmental Biology, College of Dentistry, Chosun University, Gwang-ju, Korea, 5 Department of Biochemistry, Program in Neuroscience, Developmental Genomics Group and Center of Excellence in Bioinformatics and Life Sciences, School of Medicine and Biomedical Science, State University of New York at Buffalo, Buffalo, New York, United States of America, 6 Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, United States of America Abstract Transforming growth factor- b1 (TGF-b1) signaling plays a key role in vertebrate development, homeostasis, and disease. Nuclear factor I-C (NFI-C) has been implicated in TGF-b1 signaling, extracellular matrix gene transcription, and tooth root development. However, the functional relationship between NFI-C and TGF-b1 signaling remains uncharacterized. The purpose of this study was to identify the molecular interactions between NFI-C and TGF-b1 signaling in mouse odontoblasts. Real-time polymerase chain reaction and
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