correlation of the rates of solvolysis of two arenesulfonyl chlorides and of trans-β-styrenesulfonyl chloride — precursors in the development of new pharmaceuticals的溶剂分解率的相关性两个arenesulfonyl氯化物和氯化trans-β-styrenesulfonylu2014u2014在开发新药物前体.pdfVIP

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correlation of the rates of solvolysis of two arenesulfonyl chlorides and of trans-β-styrenesulfonyl chloride — precursors in the development of new pharmaceuticals的溶剂分解率的相关性两个arenesulfonyl氯化物和氯化trans-β-styrenesulfonylu2014u2014在开发新药物前体.pdf

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correlation of the rates of solvolysis of two arenesulfonyl chlorides and of trans-β-styrenesulfonyl chloride — precursors in the development of new pharmaceuticals的溶剂分解率的相关性两个arenesulfonyl氯化物和氯化trans-β-styrenesulfonylu2014u2014在开发新药物前体

Int. J. Mol. Sci. 2008, 9, 2639-2657; DOI: 10.3390/ijms9122639 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms/ Article Correlation of the Rates of Solvolysis of Two Arenesulfonyl Chlorides and of trans-β-Styrenesulfonyl Chloride – Precursors in the Development of New Pharmaceuticals Zoon Ha Ryu 1,*, Sang Wok Lee 1, Malcolm J. D’Souza 2,*, Lamia Yaakoubd 2, Samantha E. Feld 2 and Dennis N. Kevill 3,* 1 Department of Chemistry, Dong-Eui University, 24 Kaya-dong, Busan-Jin-Gu, Busan 614-714, Korea 2 Department of Chemistry, Wesley College, 120 N. State Street, Dover, Delaware 19901-3875, USA 3 Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115- 2862, USA * Authors to whom correspondence should be addressed; E-Mails: dsouzama@ (M. D.); zhryu@deu.ac.kr (Z. R.); dkevill@ (D. K.) Received: 21 November 2008; in revised form: 16 December 2008 / Accepted: 17 December 2008 / Published: 17 December 2008 Abstract: Additional specific rates of solvolysis have been determined, mainly in fluoroalcohol containing solvents, for benzenesulfonyl chloride (1) and p -nitrobenzene- sulfonyl chloride (2). For trans-β-styrenesulfonyl chloride (3), a study has been carried out in 43 pure and binary solvents, covering a wide range of hyroxylic solvent systems. For the specific rates of solvolyses of each of the three substrates, a good correlation was obtained over the full range of solve