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comt val158met polymorphism and neural pain processingcomt val158met多态性和神经疼痛处理
COMT val158met Polymorphism and Neural Pain Processing 1. ¨ 1 . 2. 1 1 Christian Schmahl , Petra Ludascher * , Wolfgang Greffrath , Anja Kraus , Gabriele Valerius , 3 4 4 5 1 Thomas G. Schulze , Jens Treutlein , Marcella Rietschel , Michael N. Smolka , Martin Bohus 1 Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany, 2 Division of Neurophysiology, Center of Biomedicine and Medical Technology, Mannheim, Germany, 3 Department of Psychiatry and Psychotherapy, University Medical Center, Goettingen, Germany, 4 Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Mannheim, Germany, 5 Department of Psychiatry and Psychotherapy, Technische ¨ Universitat Dresden, Dresden, Germany Abstract A functional polymorphism (val158met) of the gene coding for Catechol-O-methyltransferase (COM) has been demonstrated to be related to processing of emotional stimuli. Also, this polymorphism has been found to be associated with pain regulation in healthy subjects. Therefore, we investigated a possible influence of this polymorphism on pain processing in healthy persons as well as in subjects with markedly reduced pain sensitivity in the context of Borderline Personality Disorder (BPD). Fifty females (25 patients with BPD and 25 healthy control participants) were included in this study. Genotype had a significant – though moderate - effect on pain sensitivity, but only in healthies. The number of val alleles was co
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