constitutive tl1a (tnfsf15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis本构tl1a(tnfsf15)表情淋巴或髓细胞导致轻微的肠道炎症和纤维化.pdfVIP

Constitutive TL1A (TNFSF15) Expression on Lymphoid or Myeloid Cells Leads to Mild Intestinal Inflammation and Fibrosis 1 1 1,2 1 3 David Q. Shih , Robert Barrett , Xiaolan Zhang , Nicole Yeager , Hon Wai Koon , Piangwarin 1 3 1 1 1 1 Phaosawasdi , Yahui Song , Brian Ko , Michelle H. Wong , Kathrin S. Michelsen , Gislaine Martins , 3 1 Charalabos Pothoulakis , Stephan R. Targan * 1 Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, 2 Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijianzuang, China, 3 Division of Digestive Diseases, Inflammatory Bowel Disease Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Abstract TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease patients. Moreover, a subset of Crohn’s disease (CD) patients with the risk TL1A haplotype is associated with elevated TL1A expression and a more severe disease course. To investigate the in vivo role of elevated TL1A expression, we generated two transgenic (Tg) murine models with constitutive Tl1a expression in either lymphoid or myeloid cells. Compared to wildtype (WT) mice, constitutive expression of Tl1a in either lymphoid or myeloid cells showed mild patchy inflammation in the small intestine, which was more prominent in the ileum. In addition, mice with constitutive Tl1a expression exhibited e