有哪些信誉好的足球投注网站conserved expression of the glutamate nmda receptor 1 subunit splice variants during the development of the siberian hamster suprachiasmatic nucleus守恒的表达谷氨酸nmda受体1单元拼接变体在西伯利亚仓鼠视交叉上核的发展.pdfVIP
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conserved expression of the glutamate nmda receptor 1 subunit splice variants during the development of the siberian hamster suprachiasmatic nucleus守恒的表达谷氨酸nmda受体1单元拼接变体在西伯利亚仓鼠视交叉上核的发展
Conserved Expression of the Glutamate NMDA Receptor 1 Subunit Splice Variants during the Development of the Siberian Hamster Suprachiasmatic Nucleus 1 2 3 Giles E. Duffield *, Jens D. Mikkelsen , Francis J. P. Ebling 1 Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, United States of America, 2 Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 3 School of Biomedical Sciences, University of Nottingham Medical School, Nottingham, United Kingdom Abstract Glutamate neurotransmission and the N-methyl-D-aspartate receptor (NMDAR) are central to photic signaling to the master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). NMDARs also play important roles in brain development including visual input circuits. The functional NMDAR is comprised of multiple subunits, but each requiring the NR1 subunit for normal activity. The NR1 can be alternatively spliced to produce isoforms that confer different functional properties on the NMDAR. The SCN undergoes extensive developmental changes during postnatal life, including synaptogenesis and acquisition of photic signaling. These changes are especially important in the highly photoperiodic Siberian hamster, in which development of sensitivity to photic cues within the SCN could impact early physiological programming. In this study we examined the expression of NR1 isoforms in the hamster at different developmental ages. Gene expression in the forebrain was quantified by in situ hybridization using oligonucleotide probes specific to alternatively spliced regions of the NR1 heteronuclear mRNA, including examination of anterior hypothalamus, piriform
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