有哪些信誉好的足球投注网站conserved bk channel-protein interactions reveal signals relevant to cell death and survival守恒的bk channel-protein交互显示信号与细胞死亡和生存有关.pdfVIP
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conserved bk channel-protein interactions reveal signals relevant to cell death and survival守恒的bk channel-protein交互显示信号与细胞死亡和生存有关
Conserved BK Channel-Protein Interactions Reveal Signals Relevant to Cell Death and Survival 1 2. 1. 3 1 Bernd Sokolowski *, Sandra Orchard , Margaret Harvey , Settu Sridhar , Yoshihisa Sakai 1 Otology Laboratory, Department of Otolaryngology – Head and Neck Surgery, University of South Florida, College of Medicine, Tampa, Florida, United States of America, 2 European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, United Kingdom, 3 Department of Informatics, University of Bergen, Bergen, Norway Abstract The large-conductance Ca2+-activated K+ (BK) channel and its b-subunit underlie tuning in non-mammalian sensory or hair cells, whereas in mammals its function is less clear. To gain insights into species differences and to reveal putative BK functions, we undertook a systems analysis of BK and BK-Associated Proteins (BKAPS) in the chicken cochlea and compared these results to other species. We identified 110 putative partners from cytoplasmic and membrane/cytoskeletal fractions, using a combination of coimmunoprecipitation, 2-D gel, and LC-MS/MS. Partners included 14-3-3c, valosin-containing protein (VCP), stathmin (STMN), cortactin (CTTN), and prohibitin (PHB), of which 16 partners were verified by reciprocal coimmunoprecipitation. Bioinformatics revealed binary partners, the resultant interactome, subcellular localization, and cellular processes. The interactome contained 193 proteins involved in 190 binary interactions in subcellular compartments such as the ER, mitochondria, and nucleus. Comparisons with mice showed shared hub proteins that included N-methyl-D- aspartate receptor (NMDAR) and
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