congenital sensorineural deafness in australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to cfa10先天性感音神经性耳聋在澳大利亚stumpy-tail牧牛犬是一种常染色体隐性特质,映射到cfa10.pdfVIP

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congenital sensorineural deafness in australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to cfa10先天性感音神经性耳聋在澳大利亚stumpy-tail牧牛犬是一种常染色体隐性特质,映射到cfa10.pdf

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congenital sensorineural deafness in australian stumpy-tail cattle dogs is an autosomal recessive trait that maps to cfa10先天性感音神经性耳聋在澳大利亚stumpy-tail牧牛犬是一种常染色体隐性特质,映射到cfa10

Congenital Sensorineural Deafness in Australian Stumpy- Tail Cattle Dogs Is an Autosomal Recessive Trait That Maps to CFA10 1 3 1 1 1 Susan Sommerlad , Allan F. McRae , Brenda McDonald , Isobel Johnstone , Leigh Cuttell , Jennifer M. 1 2 Seddon , Caroline A. O’Leary * 1 School of Veterinary Science, The University of Queensland, Gatton, Queensland, Australia, 2 Centre for Companion Animal Health, The University of Queensland, Brisbane, Queensland, Australia, 3 Queensland Statistical Genetics, Queensland Institute of Medical Research, Brisbane, Queensland, Australia Abstract Background: Congenital sensorineural deafness is an inherited condition found in many dog breeds, including Australian Stumpy-tail Cattle Dogs (ASCD). This deafness is evident in young pups and may affect one ear (unilateral) or both ears (bilateral). The genetic locus/loci involved is unknown for all dog breeds. The aims of this study were to determine incidence, inheritance mechanism, and possible association of congenital sensorineural deafness with coat colour in ASCD and to identify the genetic locus underpinning this disease. Methodology/Principal Findings: A total of 315 ASCD were tested for sensorineural deafness using the brain stem auditory evoked response (BAER) test. Disease penetrance was estimated directly, using the ratio of unilaterally to bilaterally deaf dogs, and segregation analysis was performed using Mendel. A complete genome screen was undertaken using 325 microsatellites spread throughout the genome, on a pedigree of 50 BAER tested ASCD in which deafness was segregating. Fifty-six dogs (17.8%) were deaf, with 17 bilaterally and 39 unilaterally deaf. Unilaterally deaf dogs