有哪些信誉好的足球投注网站comparative transcriptome analysis of bacillus subtilis responding to dissolved oxygen in adenosine fermentation比较转录组分析的枯草芽孢杆菌对溶解氧的腺苷酸发酵.pdfVIP
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comparative transcriptome analysis of bacillus subtilis responding to dissolved oxygen in adenosine fermentation比较转录组分析的枯草芽孢杆菌对溶解氧的腺苷酸发酵
Comparative Transcriptome Analysis of Bacillus subtilis Responding to Dissolved Oxygen in Adenosine Fermentation Wen-Bang Yu., Shu-Hong Gao., Chun-Yun Yin, Ying Zhou, Bang-Ce Ye* Lab of Biosystems and Microanalysis, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China Abstract Dissolved oxygen (DO) is an important factor for adenosine fermentation. Our previous experiments have shown that low oxygen supply in the growth period was optimal for high adenosine yield. Herein, to better understand the link between oxygen supply and adenosine productivity in B. subtilis (ATCC21616), we sought to systematically explore the effect of DO on genetic regulation and metabolism through transcriptome analysis. The microarrays representing 4,106 genes were used to study temporal transcript profiles of B. subtilis fermentation in response to high oxygen supply (agitation 700 r/min) and low oxygen supply (agitation 450 r/min). The transcriptome data analysis revealed that low oxygen supply has three major effects on metabolism: enhance carbon metabolism (glucose metabolism, pyruvate metabolism and carbon overflow), inhibit degradation of nitrogen sources (glutamate family amino acids and xanthine) and purine synthesis. Inhibition of xanthine degradation was the reason that low oxygen supply enhanced adenosine production. These provide us with potential targets, which can be modified to achieve higher adenosine yield. Expression of genes involved in energy, cell type differentiation, protein synthesis was also influenced by oxygen supply. These results provided new insights into the relationship between oxygen supply and metabolism. Citation: Yu W-B, Gao S-H, Yin C-Y, Zhou Y, Ye B-C (2011) Comparative Transcriptome Analysis of Bacillus subtilis Responding to Dissolved Oxygen in Adenosine Fermen
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