common genetic variation in the serpinf1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels常见的遗传变异serpinf1轨迹决定了整体肥胖,肥胖相关胰岛素抵抗,和循环瘦素水平.pdfVIP

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common genetic variation in the serpinf1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels常见的遗传变异serpinf1轨迹决定了整体肥胖,肥胖相关胰岛素抵抗,和循环瘦素水平.pdf

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common genetic variation in the serpinf1 locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels常见的遗传变异serpinf1轨迹决定了整体肥胖,肥胖相关胰岛素抵抗,和循环瘦素水平

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels ¨ 1,2 1,3 ¨ 3,4 1 1 Anja Bohm , Anna-Maria Ordelheide , Jurgen Machann , Martin Heni , Caroline Ketterer , 1,3 3,4 1,3 1,3,5 ¨ 1,3 Fausto Machicao , Fritz Schick , Norbert Stefan , Andreas Fritsche , Hans-Ulrich Haring , Harald Staiger1,3* ¨ ¨ 1 Department of Internal Medicine, Division of Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Eberhard Karls University Tubingen, Tubingen, Germany, 2 Institute of Experimental Genetics, Group of Translational Diabetology, Helmholtz Centre Munich, German Research Center for Environmental Health, Munich, Germany; Member of the German Centre for Diabetes Research, 3 Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Centre Munich at the University ¨ ¨ of Tubingen, Tubingen, Germany; Member of the German Centre for Diabetes Research, 4 Department of Diagnostic and Interventional Radiology, Section of ¨ ¨ Experimental Radiology, Eberhard Karls University Tubingen, Tubingen, Germany, 5 Department of Internal Medicine, Division of Nutritional and Preventive Medicine, ¨ ¨ Eberhard Karls University Tubingen, Tubingen, Germany