combinations of host biomarkers predict mortality among ugandan children with severe malaria a retrospective case-control study宿主生物标志物组合预测死亡率乌干达儿童重症疟疾回顾性病例对照研究.pdfVIP

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combinations of host biomarkers predict mortality among ugandan children with severe malaria a retrospective case-control study宿主生物标志物组合预测死亡率乌干达儿童重症疟疾回顾性病例对照研究.pdf

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combinations of host biomarkers predict mortality among ugandan children with severe malaria a retrospective case-control study宿主生物标志物组合预测死亡率乌干达儿童重症疟疾回顾性病例对照研究

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study 1 2 2 1 1 Laura K. Erdman , Aggrey Dhabangi , Charles Musoke , Andrea L. Conroy , Michael Hawkes , Sarah 1 1 3 4 1,5 Higgins , Nimerta Rajwans , Kayla T. Wolofsky , David L. Streiner , W. Conrad Liles , Christine M. 6. 1,5 . Cserti-Gazdewich , Kevin C. Kain * 1 S.A. Rotman Laboratories, McLaughlin-Rotman Centre for Global Health, Toronto General Hospital-University Health Network, University of Toronto, Toronto, Ontario, Canada, 2 Makerere University College of Health Sciences, Kampala, Uganda, 3 School of Medicine, University of Queensland, Brisbane, Queensland, Australia, 4 Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, 5 Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, Toronto General Hospital, Toronto, Ontario, Canada, 6 Laboratory Medicine Program (Transfusion Medicine), University Health Network/University of Toronto, Toronto, Ontario, Canada Abstract Background: Severe malaria is a leading cause of childhood mortality in Africa. However, at presentation, it is difficult to predict which children with severe malaria are at greatest risk of death. Dysregulated host inflammatory responses and endothelial activation play central roles in severe malaria pathogenesis. We hypothesized that biomarkers of these processes would accurately predict outcome among children with severe malaria.