有哪些信誉好的足球投注网站blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured drg neurons封锁持续钠电流有助于riluzole-induced抑制受伤drg神经元的自发活动和振荡.pdfVIP
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blockade of persistent sodium currents contributes to the riluzole-induced inhibition of spontaneous activity and oscillations in injured drg neurons封锁持续钠电流有助于riluzole-induced抑制受伤drg神经元的自发活动和振荡
Blockade of Persistent Sodium Currents Contributes to the Riluzole-Induced Inhibition of Spontaneous Activity and Oscillations in Injured DRG Neurons 1. 1. 1. 1,2. 1,4 1 Rou-Gang Xie , Da-Wei Zheng , Jun-Ling Xing , Xu-Jie Zhang , Ying Song , Ya-Bin Xie , Fang 1 3 1 1 1 Kuang , Hui Dong , Si-Wei You , Hui Xu *, San-Jue Hu * 1 Institute of Neuroscience, Xi Jing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, 2 School of Stomatology, Xi Jing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, 3 Department of Anaesthiology, Xi Jing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China, 4 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou, People’s Republic of China Abstract In addition to a fast activating and immediately inactivating inward sodium current, many types of excitable cells possess a noninactivating or slowly inactivating component: the persistent sodium current (INaP). The INaP is found in normal primary sensory neurons where it is mediated by tetrodotoxin-sensitive sodium channels. The dorsal root ganglion (DRG) is the gateway for ectopic impulses that originate in pathological pain signals from the periphery. However, the role of INaP in DRG neurons remains unclear, particularly in neuropathic pain states. Using in vivo recordings from single medium- and large- diameter fibers isolated from the compressed DRG in Sprague-Dawley rats, we show that local application of riluzole, which blocks the INaP, also inhibits the spontaneous activity of A-type DRG neurons in a
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