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using bioinformatic approaches to identify pathways targeted by human leukemogens利用生物信息学方法确定人类leukemogens通路的目标.pdf

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using bioinformatic approaches to identify pathways targeted by human leukemogens利用生物信息学方法确定人类leukemogens通路的目标

Int. J. Environ. Res. Public Health 2012, 9, 2479-2503; doi:10.3390/ijerph9072479 OPEN ACCESS International Journal of Environmental Research and Public Health ISSN 1660-4601 /journal/ijerph Article Using Bioinformatic Approaches to Identify Pathways Targeted by Human Leukemogens Reuben Thomas, Jimmy Phuong, Cliona M. McHale and Luoping Zhang * Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA; E-Mails: reuben.thomas@ (R.T.); j_phuong@ (J.P.); cmchale@ (C.M.M.) * Author to whom correspondence should be addressed; E-Mail: luoping@; Tel.: +1-510-643-5189; Fax: +1-510-642-0427. Received: 18 May 2012; in revised form: 25 June 2012 / Accepted: 26 June 2012 / Published: 12 July 2012 Abstract: We have applied bioinformatic approaches to identify pathways common to chemical leukemogens and to determine whether leukemogens could be distinguished from non-leukemogenic carcinogens. From all known and probable carcinogens classified by IARC and NTP, we identified 35 carcinogens that were associated with leukemia risk in human studies and 16 non-leukemogenic carcinogens. Using data on gene/protein targets available in the Comparative Toxicogenomics Database (CTD) for 29 of the leukemogens and 11 of the non-leukemogenic carcinogens, we analyzed for enrichment