the cycle of genome-directed medicinegenome-directed医学的循环.pdfVIP

Editorial TThhee ccyyccllee ooff ggeennoommee--ddiirreecctteedd mmeeddiicciinnee Janet A Buchanan*, Andrew R Carson*†¥, David Chitayat§#, David Malkin†‡#**, M Stephen Meyn†§¥, Peter N Ray*¶¥, Cheryl Shuman§¥, Rosanna Weksberg†§# and Stephen W Scherer*†¥ Addresses: *The Centre for Applied Genomics, †Research Institute Program in Genetics and Genome Biology, ‡Division of Hematology/Oncology, Department of Pediatrics, §Division of Clinical Metabolic Genetics, Department of Paediatrics and ¶Department of Pediatric Laboratory Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. ¥Department of Molecular Genetics, #Department of Pediatrics and **Department of Medical Biophysics, The University of Toronto, 27 King’s College Circle, Toronto, ON M5S 1A1, Canada. Correspondence: Stephen W Scherer. Email: steve@genet.sickkids.on.ca Published: 2 February 2009 Genome Medicine 2009, 11:: 16 (doi:10.1186/gm16) The electronic version of this article is the complete one and can be found online at /content/1/2/16 © 2009 BioMed Central Ltd AAbbssttrraacctt The genome era in medicine is upon us. Questions that arise from patient and family care are a watershed for research and technology, which in turn fuel the cycle of opportunity for impact through delivery of health services, which feeds back to families. Medical infrastructure needs to adapt to the dramatic pace of technology development in the wake of the Human Genome Project, in order for genome data to be delivered as information and applied as knowledge to benefit health. GGeennoommeess ttoo mmeeddiicciinnee paradigm in biomedicine. The term ‘directs’ quite explicitly Medical practice and research have entered the genome era. describes the role of the genome with r