the crest phenotype in chicken is associated with ectopic expression of hoxc8 in cranial skin鸡的波峰表型与异位表达的hoxc8颅皮肤.pdfVIP

The Crest Phenotype in Chicken Is Associated with Ectopic Expression of HOXC8 in Cranial Skin 1 1 2 1 1 1 1,3 Yanqiang Wang , Yu Gao , Freyja Imsland , Xiaorong Gu , Chungang Feng , Ranran Liu , Chi Song , ` 4 5 1 3 3 Michele Tixier-Boichard , David Gourichon , Qingyuan Li , Kuanwei Chen , Huifang Li , 2,6 1 1 Leif Andersson , Xiaoxiang Hu *, Ning Li * 1 State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, China, 2 Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, 3 Jiangsu lnstitute of Poultry Science, Yangzhou, China, 4 INRA, AgroParisTech, UMR1313 Animal Genetics and Integrative Biology, Jouy-en-Josas, France, 5 INRA, UE1295 PEAT, Nouzilly, France, 6 Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden Abstract The Crest phenotype is characterised by a tuft of elongated feathers atop the head. A similar phenotype is also seen in several wild bird species. Crest shows an autosomal incompletely dominant mode of inheritance and is associated with cerebral hernia. Here we show, using linkage analysis and genome-wide association, that Crest is located on the E22C19W28 linkage group and that it shows complete association to the HOXC-cluster on this chromosome. Expression analysis of tissues from Crested and non-crested chickens, representing 26 different breeds, revealed that HOXC8, but not HOXC12 or HOXC13, showed ectopic expression in c