有哪些信誉好的足球投注网站targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising pkc activity and cytokinesis针对鞘氨醇激酶1在癌细胞减少损害pkc活性和胞质分裂增殖和生存.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising pkc activity and cytokinesis针对鞘氨醇激酶1在癌细胞减少损害pkc活性和胞质分裂增殖和生存
Targeting Sphingosine Kinase 1 in Carcinoma Cells Decreases Proliferation and Survival by Compromising PKC Activity and Cytokinesis 1 2 1,3 1,4 Nataliya Kotelevets , Doriano Fabbro , Andrea Huwiler , Uwe Zangemeister-Wittke * 1 Institute of Pharmacology, University of Bern, Bern, Switzerland, 2 Novartis Pharma AG, NIBR Basel, Switzerland, 3 Pharmazentrum Frankfurt/ZAFES, University Hospital ¨ ¨ Frankfurt, Frankfurt am Main, Germany, 4 Institute of Biochemistry, University of Zurich, Zurich, Switzerland Abstract Sphingosine kinases (SK) catalyze the phosphorylation of proapoptotic sphingosine to the prosurvival factor sphingosine 1- phosphate (S1P), thereby promoting oncogenic processes. Breast (MDA-MB-231), lung (NCI-H358), and colon (HCT 116) carcinoma cells were transduced with shRNA to downregulate SK-1 expression or treated with a pharmacologic SK-1 inhibitor. The effects of SK-1 targeting were investigated by measuring the level of intracellular sphingosine, the activity of protein kinase C (PKC) and cell cycle regulators, and the mitotic index. Functional assays included measurement of cell proliferation, colony formation, apoptosis, and cell cycle analysis. Downregulation of SK-1 or its pharmacologic inhibition increased intracellular sphingosine and decreased PKC activity as shown by reduced phosphorylation of PKC substrates. In MDA-MB-231 cells this effect was most pronounced and reduced cell proliferation and colony formation, which could be mimicked using exogenous sphingosine or the PKC inhibitor RO 31-8220. SK-1 downregulation in MDA-MB-231 cells increa
您可能关注的文档
- synthesis of 2- and 7- substituted c19 steroids having a 1,4,6-triene or 1,4-diene structure and their cytotoxic effects on t47d and mda-mb231 breast cancer cells合成2 -和7 -取代c19类固醇1,4,6-triene或1,4-diene结构及其对t47d细胞毒性影响和mda-mb231乳腺癌细胞.pdf
- synthesis of [2′-(n-ethylamino)-5′-alkyl]phenyl-5,6,7,8-tetrahydroacridine-9-carboxy-2-sulfone derivatives by the proton-catalyzed rearrangement of corresponding sulfonamides英文论文.pdf
- synthesis of 2-(4,6-dimethoxy-1,3,5-triazin-2-yloxyimino) derivatives application in solution peptide synthesis合成2 -(4 6-dimethoxy-1 5-triazin-2-yloxyimino)多肽合成衍生产品应用解决方案.pdf
- synthesis of (2-chloropyridine-3-yl)-(4-nitrobenzylidene) amine and its antibacterial activity(2-chloropyridine-3-yl)u2014u2014(4-nitrobenzylidene)胺的合成及其抗菌活性.pdf
- synthesis of 2-(9,10-dihydro-9,10-propanoanthracen-9-yl)-n-methylethanamine via a [4+2] cycloaddition合成2 -(9 10-dihydro-9 10-propanoanthracen-9-yl)-n-methylethanamine通过[4 + 2]环加成作用.pdf
- synthesis of 2-(4-methoxyphenyl)pyrrolo[2,1-d]pyrido[2,3-c]-[1,5]-thiazepin-3(2h)-one合成2 -(4-methoxyphenyl)pyrrolo[2,一维]pyrido[2,3 c]-[1,5]-thiazepin-3u2014u2014(2 h).pdf
- synthesis of 2-(2-aminopyrimidine)-2,2-difluoroethanols as potential bioisosters of salicylidene acylhydrazides合成2 -(2-aminopyrimidine)2,2-difluoroethanols的潜在bioisosters salicylidene acylhydrazides.pdf
- synthesis of 2,4,6-tri-substituted-1,3,5-triazines合成2,4,6-tri-substituted-1 3 5-triazines.pdf
- synthesis of 2,3-dioxo-5-(substituted)arylpyrroles and their 2-oxo-5-aryl-3-hydrazone pyrrolidine derivatives合成2,3-dioxo-5 -(取代)arylpyrroles及其2-oxo-5-aryl-3-hydrazone吡咯烷衍生品.pdf
- synthesis of 2,7-bis(fluoromethyl)naphthalene合成2,7-bis(fluoromethyl)萘.pdf
- targeting the dna double strand break repair machinery in prostate cancer针对前列腺癌dna双链断裂修复机器.pdf
- targeting the anti-apoptotic protein c-flip for cancer therapy针对抗凋亡蛋白c-flip癌症治疗.pdf
- targeting the lactate transporter mct1 in endothelial cells inhibits lactate-induced hif-1 activation and tumor angiogenesis针对乳酸转运体在内皮细胞抑制mct1 lactate-induced hif-1激活和肿瘤血管生成.pdf
- targeting the tumour cell penetrating peptides for molecular imaging and radiotherapy针对肿瘤细胞穿透肽分子成像和放射治疗.pdf
- targeting the ubiquitin proteasome pathway for the treatment of septic shock in patients针对泛素蛋白酶体途径治疗感染性休克的病人.pdf
- targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and dna replication针对硫氧还蛋白还原酶1减少癌细胞抑制自给自足的生长和dna复制.pdf
- targeting the large subunit of human ribonucleotide reductase for cancer chemotherapy针对人类核苷酸还原酶大亚基对癌症化疗.pdf
- targeting the mammalian target of rapamycin (mtor) in cancer therapy lessons from past and future perspectives针对哺乳动物雷帕霉素靶(mtor)从过去和未来的角度在癌症治疗的经验.pdf
- targeting tumour-initiating cells with trail based combination therapy ensures complete and lasting eradication of multiple myeloma tumours in vivo针对基于轨迹的联合治疗肿瘤起始细胞确保完整和持久的根除多发性骨髓瘤肿瘤体内.pdf
- targeting viral infection by microrna inhibition针对由微rna抑制病毒感染.pdf
文档评论（0）