有哪些信誉好的足球投注网站synthesis of 2- and 7- substituted c19 steroids having a 1,4,6-triene or 1,4-diene structure and their cytotoxic effects on t47d and mda-mb231 breast cancer cells合成2 -和7 -取代c19类固醇1,4,6-triene或1,4-diene结构及其对t47d细胞毒性影响和mda-mb231乳腺癌细胞.pdfVIP
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synthesis of 2- and 7- substituted c19 steroids having a 1,4,6-triene or 1,4-diene structure and their cytotoxic effects on t47d and mda-mb231 breast cancer cells合成2 -和7 -取代c19类固醇1,4,6-triene或1,4-diene结构及其对t47d细胞毒性影响和mda-mb231乳腺癌细胞
Molecules 2010, 15, 4408-4422; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of 2- and 7- Substituted C19 Steroids Having a 1,4,6- Triene or 1,4-Diene Structure and Their Cytotoxic Effects on T47D and MDA-MB231 Breast Cancer Cells Minwoo Kim and Eunsook Ma * College of Pharmacy, Catholic University of Daegu, Hayang, 712-702, Korea * Author to whom correspondence should be addressed; E-Mail: masook@cu.ac.kr; Tel. +82-53-850-3621 Fax: +82-53-850-3602. Received: 25 May 2010; in revised form: 12 June 2010 / Accepted: 17 June 2010 / Published: 21 June 2010 Abstract: 2-Chloro-, 2-bromo- and 2-azido-1,4,6-androstatriene-3,17-diones were synthesized from 1α,2α-epoxy-4,6-androstadiene-3,17-dione (2) using HCl, HBr and NaN , 3 respectively. Compound 2 was also reacted with NaCN to give 2-cyano-1,4,6- androstatriene-3,17-dione (5) and 2β-cyano-1α-hydroxy-4,6-androstadiene-3,17-dione (6). 6α,7α-Epoxy-1,4-androstadiene-3,17-dione (8) was reacted with HCl, HBr and NaN3 to form the corresponding 7β-chloro-, 7β-bromo- and 7β-azido-6α-hydroxy-1,4- androstadiene-3,17-diones. The cytotoxic activity of these compounds towards T47D (estrogen-dependent) and MDA-MB231 (estrogen-independent) breast cancer cell lines was evaluated. The 6α-hydroxy-7β-substituted analogs were mo
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