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targeting protective autophagy exacerbates uv-triggered apoptotic cell death针对保护性自噬加剧uv引起的凋亡细胞死亡
Int. J. Mol. Sci. 2012, 13, 1209-1224; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Targeting Protective Autophagy Exacerbates UV-Triggered Apoptotic Cell Death Li-Hsin Chen 1, Pei-Ming Chu 2, Yi-Jang Lee 3, Pang-Hsien Tu 4, Chin-Wen Chi 1,5, Hsin-Chen Lee 1,* and Shih-Hwa Chiou 1,5,* 1 Institute of Pharmacology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan; E-Mails: jenhsinchen@ (L.-H.C.); cwchi@.tw (C.-W.C.) 2 Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan; E-Mail: chupeiming@.tw 3 Department of Biomedical Image and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei 11221, Taiwan; E-Mail: yjlee2@.tw 4 Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan; E-Mail: btu@.tw 5 Department of Medical Research and Education, Taipei Veterans General Hospital, Taipei 11217, Taiwan * Authors to whom correspondence should be addressed; E-Mails: hclee2@.tw (H.-C.L.); shchiou@.tw (S.-H.C.); Tel.: +886-2(H.-C.L.); +886-2(S.-H.C.); Fax: +886-2 Received: 12 December 2011; in revised form: 10 January 2012 / Accepted: 12 January 2012 / Published: 20 January 2012 Abstract: Autophagy is activated by various stresses, including DNA damage, and previous studies of DNA damage-induced autophagy have focused
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