有哪些信誉好的足球投注网站synthesis, and antitumor activity of some n1-(coumarin-7-yl) amidrazones and related congeners合成,抗肿瘤活性的一些n1 - coumarin-7-yl amidrazones及相关副产品.pdfVIP
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synthesis, and antitumor activity of some n1-(coumarin-7-yl) amidrazones and related congeners合成,抗肿瘤活性的一些n1 - coumarin-7-yl amidrazones及相关副产品
Molecules 2011, 16, 4305-4317; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, and Antitumor Activity of Some N1-(Coumarin-7-yl) Amidrazones and Related Congeners 1 1 2 3 Mohammad S. Mustafa , Mustafa M. El-Abadelah , Malek A. Zihlif , Randa G. Naffa and Mohammad S. Mubarak 1,* 1 Department of Chemistry, The University of Jordan, Amman 11942, Jordan 2 Department of Pharmacology, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan 3 Molecular Biology Research Laboratory, Faculty of Medicine, The University of Jordan, Amman 11942, Jordan * Author to whom correspondence should be addressed; E-Mail: mmubarak@.jo; Tel.: +96-26-535-5000 Ext. 22021; Fax: +96-26-530-0253. Received: 8 April 2011; in revised form: 9 May 2011 / Accepted: 11 May 2011 / Published: 24 May 2011 Abstract: A series of new N 1-(coumarin-7-yl)amidrazones incorporating N-piperazines and related congeners were synthesized by reacting the hydrazonoyl chloride derived from 7-amino-4-methylcoumarin with the appropriate piperazines. The chemical structures of the newly prepared compounds were supported by elemental analyses, 1H-NMR, 13C-NMR, and ESI-HRMS spectral data. The antitumor activity of the newly synthesized compounds was evaluated. Among all the compounds tested, 7-{2-[1-(4-(1-benzyl-2-ethyl- 4-nitro-1H-imidazol-5-yl)piperazin-1-yl)-2-oxopropylidene
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