synthesis, antioxidant and antimicrobial activity of a new phloridzin derivative for dermo-cosmetic applications合成、抗氧化和抗菌活性的新根皮苷衍生物dermo-cosmetic应用程序.pdfVIP

Molecules 2012, 17, 13275-13289; doi:10.3390/molecules171113275 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Antioxidant and Antimicrobial Activity of a New Phloridzin Derivative for Dermo-Cosmetic Applications 1 1 1 2 Anna Baldisserotto , Gemma Malisardi , Emanuela Scalambra , Elisa Andreotti , Carlo Romagnoli 2,Chiara Beatrice Vicentini 1, Stefano Manfredini 1,3 and Silvia Vertuani 1,3,* 1 Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 17-19, 44121 Ferrara, Italy; E-Mails: bldnna@unife.it (A.B.); gemma.malisardi@unife.it (G.M.); emanuela.scalambra@unife.it (E.S.); chiara.vicentini@unife.it (C.B.V.); mv9@unife.it (S.M.) 2 Department of Life Sciences, University of Modena and Reggio Emilia, viale Caduti in Guerra 127, 41121 Modena, Italy; E-Mails: elisa.andreotti@unimore.it (E.A.); carlo.romagnoli@unimore.it (C.R.) 3 Ambrosialab, Via Mortara 171, 44121 Ferrara, Italy * Author to whom correspondence should be addressed; E-Mail: mv9@unife; Tel.: +39-0532-455294; Fax: +39-0532-455378. Received: 7 September 2012; in revised form: 25 October 2012 / Accepted: 29 October 2012 / Published: 7 November 2012 Abstract: The phenolic compound phloridzin (phloretin 2′-O-glucoside, variously named phlorizin, phlorrhizin, phlorhizin or phlorizoside) is a prominent member of the chemical class of dihydrochalcones, which are phenylpropanoids. Phloridzin is specifically found i