synthesis, characterization and cytotoxicity of new rotundic acid derivatives合成、表征和细胞毒性的新rotundic酸衍生品.pdfVIP

Molecules 2012, 17, 1278-1291; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis, Characterization and Cytotoxicity of New Rotundic Acid Derivatives Yu-Fang He 1,2,†, Min-Lun Nan 2,†, Jia-Ming Sun 3, Zhao-Jie Meng 4, Fa-Gui Yue 1, Quan-Cheng Zhao 2, Xiao-Hong Yang 1,* and Hui Wang 5,* 1 School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China; E-Mails: he_yufang1992@163.com (Y.-F.H.); agui_228@126.com (F.-G.Y.) 2 Jilin Academy of Chinese Medicine Sciences, Changchun 130012, China; E-Mails: nanminlun2000@163.com (M.-L.N.); zhaoquancheng1954@126.com (Q.-C.Z.) 3 Development Center of Traditional Chinese Medicine and Bioengineering, Changchun University of Chinese Medicine, Changchun 130117, China; E-Mail: sun_jiaming2008@163.com 4 Norman Bethune College of Medicine, Jilin University, Changchun 130021, China; E-Mail: mengzhaojie5555@163.com 5 China-Japan Union Hospital, Jilin University, Changchun 130033, China † These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: yang_xiaohong88@126.com (X.-H.Y.); wanghui_1962@126.com (H.W.); Tel.: +86-431-8605-8683 (X.-H.Y.); Fax: +86-431-8605-8672 (X.-H.Y.). Received: 5 December 2011; in revisedform: 17 January 2012 / Accepted: 20 January 2012 / Published: 31 January 2012 Abstract: Rotundic acid (RA, 1), a natural compound, exhibits potent tumor cell growth inhibiting properties. To date there are no reports on derivatives of RA. Furthermore, the 28-COOH position