synthesis of ginkgolic acid analogues and evaluation of their molluscicidal activity银杏酸类似物的合成和评估他们的molluscicidal活动.pdfVIP

Molecules 2011, 16, 4059-4069; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of Ginkgolic Acid Analogues and Evaluation of Their Molluscicidal Activity 1 1 2 2 1 3 Peng Zhang , Jiahu Pan ,Wanxing Duan , Xuedong Li , Yao Zhang , Yibiao Zhou , Qingwu Jiang 3, Zuohua Mao 2,* and Peizhong Yu 1,* 1 School of Pharmacy, Fudan University, Shanghai 201203, China 2 Shanghai Medical College, Fudan University, Shanghai 200032, China 3 School of Public Health, Fudan University, Shanghai 200032, China * Author to whom correspondence should be addressed; E-Mails: zhmao@ (Z.M.); pzyu@ (P.Y.); Tel.: +86 21(Z.M.); E-Mail: Tel.: +86 21(P.Y.). Received: 16 March 2011; in revised form: 23 April 2011 / Accepted: 9 May 2011 / Published: 17 May 2011 Abstract: Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths. Keywords: ginkgolic acid analogues; synthesis; molluscicidal activi