有哪些信誉好的足球投注网站synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives合成和反人类免疫缺陷病毒1型(e)活动-n-phenylstyryl-n-alkylacetamide衍生品.pdfVIP
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synthesis and anti-human immunodeficiency virus type 1 activity of (e)-n-phenylstyryl-n-alkylacetamide derivatives合成和反人类免疫缺陷病毒1型(e)活动-n-phenylstyryl-n-alkylacetamide衍生品
Molecules 2009, 14, 3176-3186; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Anti-Human Immunodeficiency Virus Type 1 Activity of (E)-N-Phenylstyryl-N-alkylacetamide Derivatives 1, 2 3 3 3 Pi Cheng *, Ji-Jun Chen , Ning Huang , Rui-Rui Wang , Yong-Tang Zheng and 1 Yi-Zeng Liang 1 School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China 2 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, the Chinese Academy of Sciences, Kunming 650204, China 3 Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China * Author to whom correspondence should be addressed; E-mail: picheng55@126.com; Tel.: +86-731-8836376. Received: 1 July 2009; in revised form: 30 July 2009 / Accepted: 26 August 2009 / Published: 26 August 2009 Abstract: A series of (E)-N-phenylstyryl-N-alkylacetamides, 5, were synthesized by direct reduction-acetylation of β-arylnitroolefins, followed by N-alkylation. The title compounds were characterized by 1H-NMR, EIMS and IR analysis. All the synthesized compounds were assayed as HIV-1 non-nucleoside reverse transcriptase inhibitors. A SAR study
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