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synthesis and antifungal activity of 5-chloro-6-phenylpyridazin-3(2h)-one derivatives合成和抗真菌活性5-chloro-6-phenylpyridazin-3(2 h)u2014u2014衍生品.pdf

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synthesis and antifungal activity of 5-chloro-6-phenylpyridazin-3(2h)-one derivatives合成和抗真菌活性5-chloro-6-phenylpyridazin-3(2 h)u2014u2014衍生品

Molecules 2009, 14, 3676-3687; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis and Antifungal Activity of 5-Chloro-6-Phenyl- pyridazin-3(2H)-one Derivatives Jian Wu, Baoan Song *, Hongjun Chen, Pinaki Bhadury and Deyu Hu Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Research and Development Center for Fine Chemicals, Guizhou University, Guiyang 550025, China; E-Mails: jianwu2691@ (J.W.); chj020726@163.com (H-J.C.); bhadury@ (P.B.); dyhu@ (D.H.) * Author to whom correspondence should be addressed; E-Mail: songbaoan22@; Tel.: +86 851 362 0521; Fax: +86 851 362 2211. Received: 27 July 2009; in revised form: 13 September 2009 / Accepted: 16 September 2009 / Published: 18 September 2009 Abstract: An effective method has been developed for the preparation under mild conditions of novel pyridazine derivatives from the easily accessible starting materials mucochloric acid and benzene. All the synthesized compounds were fully characterized and some of them displayed good antifungal activities against G. zeae, F. oxysporum and C. mandshurica in preliminary antifungal activity tests. Keywords: pyridazine derivatives; synthesis; antifungal activity 1. Introduction Many pyridazine derivatives are well known to possess a wide range of bioactivities and are often employed as plant virucides [1,2], antitumor agents [3-5], fungicides [6-8], insecticides [9,10], herbicides [11-15] a