surface markers for chondrogenic determination a highlight of synovium-derived stem cells表面标记chondrogenic确定synovium-derived干细胞的一大亮点.pdfVIP

Cells 2012, 1, 1107-1120; doi:10.3390/cells1041107 OPEN ACCESS cells ISSN 2073-4409 /journal/cells Review Surface Markers for Chondrogenic Determination: A Highlight of Synovium-Derived Stem Cells Douglas D. Campbell 1 and Ming Pei 1,2,3,* 1 Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown 26506, WV, USA; E-Mail: ddcampbell88@ 2 Division of Exercise Physiology, West Virginia University, Morgantown 26506, WV, USA 3 Mechanical and Aerospace Engineering, West Virginia University, Morgantown 26506, WV, USA * Author to whom correspondence should be addressed; E-Mail: mpei@; Tel.: +1-304-293-1072; Fax: +1-304-293-7070. Received: 24 September 2012; in revised form: 31 October 2012 / Accepted: 12 November 2012 / Published: 16 November 2012 Abstract: Cartilage tissue engineering is a promising field in regenerative medicine that can provide substantial relief to people suffering from degenerative cartilage disease. Current research shows the greatest chondrogenic potential for healthy articular cartilage growth with minimal hypertrophic differentiation to be from mesenchymal stem cells (MSCs) of synovial origin. These stem cells have the capacity for differentiation into multiple cell lineages related to mesenchymal tissue; however, evidence exists for cell surface markers that specify a greater potential for cho