structural antitumoral activity relationships of synthetic chalcones合成化合物的结构antitumoral活动关系.pdfVIP

Int. J. Mol. Sci. 2009, 10, 221-231; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article Structural Antitumoral Activity Relationships of Synthetic Chalcones Cesar Echeverria 1, Juan Francisco Santibañez 1, Oscar Donoso-Tauda 2, Carlos A. Escobar 2 and Rodrigo Ramirez-Tagle 2,* 1 Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile. E-Mails: cecheverrriae@ (C. E.); jfsatib@inta.cl (J. S.) 2 Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile. E-Mails: o.donoso@ (O. D.); cescobar@unab.cl (C. E.) * Author to whom correspondence should be addressed; E-Mail: ralquim@; Tel. +56-2-6615880 Received: 30 September 2008; in revised form: 31 December 2008 / Accepted: 4 January 2009 / Published: 9 January 2009 Abstract: Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2’-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and th