studies on polyethers produced by red algae研究聚醚生产的红色海藻.pdfVIP

Mar. Drugs 2010, 8, 1178-1188; doi:10.3390/md8041178 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Studies on Polyethers Produced by Red Algae Francisco Cen-Pacheco 1, Laurette Nordström 1, María Luisa Souto 1, Manuel Norte Martín 1,*, José Javier Fernández 1,* and Antonio Hernández Daranas 1,2,* 1 Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO), Universidad de La Laguna (ULL), Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain 2 Departamento de Ingeniería Química y Tecnología Farmacéutica, Universidad de La Laguna (ULL), Astrofísico Francisco Sánchez 1, 38071, La Laguna, Tenerife, Spain * Authors to whom correspondence should be addressed; E-Mails: mnorte@ull.es (M.N.M.); jjfercas@ull.es (J.J.F.); adar anas@ull.es (A.H.D.); Tel.: +34-922-318-586; Fax: +34-922-318-571. Received: 21 February 2010; in revised form: 8 March 2010 / Accepted: 22 March 2010 / Published: 7 April 2010 Abstract: Two novel squalene-derived triterpenes, spirodehydrovenustatriol (3) and 14-keto-dehydrothyrsiferol (4) were isolated from the red alga Laurencia viridis , together with two new and unusual C17 terpenoids, adejen A (5) and B (6). These truncated structures possess structural similarities with other known squalene metabolites and their biogenetic origin has been proposed on the basis of an oxidative process of the squalene skeleton. All the structures were elucidated by extensive use of 2D NMR spectroscopic methods. Key