structure-composition-property relationships in polymeric amorphous calcium phosphate-based dental compositesstructure-composition-property关系聚合物非晶体钙磷酸盐牙科复合材料.pdfVIP

Materials 2009, 2, 1929-1954; doi:10.3390/ma2041929 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Structure-Composition-Property Relationships in Polymeric Amorphous Calcium Phosphate-Based Dental Composites † Justin N.R. O’Donnell 1, Gary E. Schumacher 1, Joseph M. Antonucci 2 and Drago Skrtic 1,* 1 Paffenbarger Research Center, American Dental Association Foundation, Gaithersburg, 20899, MD, USA; E-Mails: justin.odonell@ (J.N.R.O’D.); gary.schumacher@ (G.E.S.) 2 Polymers Division, National Institute of Standards and Technology, Gaithersburg, 20899, MD, USA; E-Mail: joe.antonucci@ (J.M.A.) † Official contribution of NIST; not subject to copyrights in USA. * Author to whom correspondence should be addressed; E-Mail: drago.skrtic@; Tel.: 301-975-3541; Fax: 301-963-9143. Received: 30 October 2009; in revised form: 19 November 2009 / Accepted: 23 November 2009 / Published: 24 November 2009 Abstract: Our studies of amorphous calcium phosphate (ACP)-based materials over the last decade have yielded bioactive polymeric composites capable of protecting teeth from demineralization or even regenerating lost tooth mineral. The anti-cariogenic/re- mineralizing potential of these ACP composites originates from their propensity, when exposed to the oral environment, to release in a sustained manner sufficient levels of mineral-forming calcium and phosphate ions to promote formation of stable apatitic tooth mineral. However,