specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用.pdfVIP

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specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用.pdf

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specific binding of anionic porphyrin and phthalocyanine to the g-quadruplex with a variety of in vitro and in vivo applications特定绑定的阴离子卟啉和酞菁g-quadruplex各种体外和体内应用

Molecules 2012, 17, 10586-10613; doi:10.3390/molecules170910586 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Review Specific Binding of Anionic Porphyrin and Phthalocyanine to the G-Quadruplex with a Variety of in Vitro and in Vivo Applications Hidenobu Yaku 1,2,3,*, Takashi Murashima 2,3, Daisuke Miyoshi 2,3 and Naoki Sugimoto 2,3 1 Advanced Technology Research Laboratories, Panasonic Corporation, 3-4 Hikaridai, Seika-cho, Soraku-gun, Kyoto 619-0237, Japan 2 Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan; E-Mails: murasima@konan-u.ac.jp (T.M.); miyoshi@center.konan-u.ac.jp (D.M.); sugimoto@konan-u.ac.jp (N.S.) 3 Faculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Japan * Author to whom correspondence should be addressed; E-Mail: yaku.hidenobu@; Tel.: +81-774-98-2580; Fax: +81-774-98-2585. Received: 31 July 2012; in revised form: 27 August 2012 / Accepted: 29 August 2012 / Published: 5 September 2012 Abstract: The G-quadruplex, a four-stranded DNA structure with stacked guanine tetrads (G-quartets), has recently been attracting attention because of its critical roles in vitro and in vivo. In particular, the G-quadruplex functions as ligands for metal ions and aptamers for various molecules. Interestingly, the G-quadruplex can show peroxidase-like activity with an anionic porphyrin, iron (III) protoporphyrin IX (hemin). Im