冠心病患者血浆超敏C反应蛋白、血小板聚集率及D一二聚体水平测定.docVIP

冠心病患者血浆超敏C反应蛋白、血小板聚集率及D一二聚体水平测定 　【摘要】 目的研究冠心病患者血浆超敏C反应蛋白(hs-CRP)、血小板聚集率和 D-二聚体(D-D)水平及其临床相关性。方法选不同类型冠心病患者128例(冠心病组)和健康体检者40例(对照组)，分别采用免疫比浊法和自身红细胞凝集法检测血浆hs-CRP、血小板聚集率和D-D水平，并进行相关性分析。结果冠心病组血浆hs-CRP、血小板聚集率、D-D水平明显高于对照组(Plt;0.01)，且急性冠脉综合征(ACS)[急性心肌梗死(AMI)gt;不稳定型心绞痛(UA)]gt;稳定型心绞痛(SAP)gt;隐匿性冠心病，差异有显著性(P均lt;0.01)。hs-CRP、血小板聚集率和D-D三者有直线相关关系。结论hs-CRP、血小板聚集率和 D-D与冠心病发生、发展密切相关，联合检测有利于冠心病的早期诊断、临床分型、病情判断及指导临床用药。 【关键词】 冠状动脉疾病;超敏C反应蛋白;血小板聚集;D二聚体 　Abstract:ObjectiveTo study tbe levels ofhypersensitivity C-reactive protein (hs-CRP), maximal platelet aggregation (MPA), D-dimer (D-D) and to assess their clinical correlations in patients with coronary heart disease (CHD).Methods128 patients with different types of coronaryheart diseases　　(a CHDgroup) and 40 healthy subjects undergoing physical examination (a control group)were enrolled in this study. An immunity turbidimetry and self red blood cell aggregation test were used to measure the levels of plasma hs-CRP, MPA and D-D and the correlation analysis was also done.ResultsIn the CHD group, the levels of plasma hs-CRP, MPA and D-D elevated significantly, compared to the control group, there were statistically significant differences (Plt;0.01). While th　　e above indices ranged as: acute coronary syndrome (ACS) [acute myocardial infarcti　on (AMI)gt;unstable angina (UA)]gt;stable angina pectoris (SAP)gt;latent CHD, comparedamong these groups, there were statistically significant differences (all Plt;0.01). hs-CRP, MPA and D-D had linear correlation.ConclusionPlasma hs-CRP, MPA and D-D have positively associated with genesis and development of CHD, the combination detection benefits for early diagnosis, clinical typing, predicting disease and drug guidance for CHD. 　　Key words:coronary disease; hypersensitivity C-reactive protein; platelet aggregation; D-dimer 　　冠状动脉粥样硬化发生与血管壁局部炎症及机体全身炎症反应有关，机体的慢性炎症反应可能会促进冠心病的发生、发展。超敏C反应蛋白(hs-CRP)、血小板聚集率和D-二聚体(D-D)是机体炎症反应的敏感标志物，与冠心病关系密切。我们对128例不同类型冠心病患者血浆hs-CRP、血小板聚集率及D-D水平进行了测定，旨在探讨三者在冠心病