antibody response to shiga toxins in argentinean children with enteropathic hemolytic uremic syndrome at acute and long-term follow-up periods抗体反应志贺毒素在阿根廷enteropathic溶血性尿毒症综合征患儿急性和长期随访期.pdfVIP

Antibody Response to Shiga Toxins in Argentinean Children with Enteropathic Hemolytic Uremic Syndrome at Acute and Long-Term Follow-Up Periods ´ 1,2 1 ´ ´ 1,2 ´ 1 Romina J. Fernandez-Brando , Leticia V. Bentancor , Marıa Pilar Mejıas , Marıa Victoria Ramos , 3 4 ´ 4 ´ 4 ´ 1,2 Andrea Exeni , Claudia Exeni , Marıa del Carmen Laso , Ramon Exeni , Martın A. Isturiz , Marina S. Palermo1,2* ´ ´ ´ 1 Division Inmunologıa, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Ciudad de Buenos Aires, Argentina, 2 Instituto de Leucemia ´ ´ Experimental (CONICET), Buenos Aires, Argentina, 3 Servicio de Nefrologıa, Hospital Austral, Pilar, Provincia de Buenos Aires, Argentina, 4 Departamento de Nefrologıa, ˜ Hospital Municipal del Nino, San Justo, La Matanza, Provincia de Buenos Aires, Argentina Abstract Shiga toxin (Stx)-producing Escherichia coli (STEC) infection is associated with a broad spectrum of clinical manifestations that include diarrhea, hemorrhagic colitis, and hemolytic uremic syndrome (HUS). Systemic Stx toxemia is considered to be central to the genesis of HUS. Distinct methods have been used to evaluate anti-Stx response for immunodiagnostic or