anticancer alkaloid lamellarins inhibit protein kinases抗癌生物碱lamellarins抑制蛋白激酶.pdfVIP

Mar. Drugs 2008, 6, 514-527; DOI: 10.3390/m OPEN ACCESS Marine Drugs ISSN 1660-3397 /marinedrugs Article Anticancer Alkaloid Lamellarins Inhibit Protein Kinases 1 1 1 1 Dianne Baunbæk , Nolwenn Trinkler , Yoan Ferandin , Olivier Lozach , Poonsakdi Ploypradith 2, Somsak Rucirawat 2, Fumito Ishibashi , Masatomo Iwao 4 and Laurent Meijer 1,* 1 C.N.R.S., Cell Cycle Group, Station Biologique, B.P. 74, 29682 Roscoff Cedex, Bretagne, France 2 Laboratory of Medicinal Chemistry, Chulaborhn Research Institute, Vipavadee-Rangsit Highway, Bangkok 10210, Thailand 3 Division of Marine Life Science and Biochemistry, Faculty of Fisheries, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan 4 Department of Applied Chemistry, Faculty of Engineering, Nagasaki University, 1-14 Bunkyo- machi, Nagasaki 852-8521, Japan * Author to whom correspondence should be addressed; E-mail: meijer@sb-roscoff.fr Received: 2 August 2008; in revised form: 18 September 2008 / Accepted: 26 September 2008 / Published: 7 October Abstract: Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, interaction with DNA and direct effects on mitochondria. W